Abstract
Uninephrectomized rats maintained on 0.9% NaCl as drinking fluid and infused for 8 weeks with aldosterone 0.75 μg/h via subcutaneous osmotic minipumps respond with hypertension, cardiac hypertrophy, and both interstitial and perivascular cardiac fibrosis. Similar animals injected with desoxycorticosterone (20 mg/week), or the glucocorticoid antagonist RU 486 (2 mg/day) show interstitial cardiac fibrosis to a lesser degree than animals injected with aldosterone, and show perivascular fibrosis to a greater degree. These findings suggest that glucocorticoid antagonist activity may play a role in exacerbating perivascular collagen deposition in response to chronic mineralocorticoid and salt imbalance.
Original language | English |
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Pages (from-to) | 133-136 |
Number of pages | 4 |
Journal | Steroids |
Volume | 60 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jan 1995 |
Externally published | Yes |
Keywords
- aldosterone
- corticosterone
- deoxycorticosterone
- perivascular fibrosis
- RU 486, interstitial fibrosis
- salt