Adrenal steroids and cardiac fibrosis

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)


Uninephrectomized rats maintained on 0.9% NaCl as drinking fluid and infused for 8 weeks with aldosterone 0.75 μg/h via subcutaneous osmotic minipumps respond with hypertension, cardiac hypertrophy, and both interstitial and perivascular cardiac fibrosis. Similar animals injected with desoxycorticosterone (20 mg/week), or the glucocorticoid antagonist RU 486 (2 mg/day) show interstitial cardiac fibrosis to a lesser degree than animals injected with aldosterone, and show perivascular fibrosis to a greater degree. These findings suggest that glucocorticoid antagonist activity may play a role in exacerbating perivascular collagen deposition in response to chronic mineralocorticoid and salt imbalance.

Original languageEnglish
Pages (from-to)133-136
Number of pages4
Issue number1
Publication statusPublished - 1 Jan 1995
Externally publishedYes


  • aldosterone
  • corticosterone
  • deoxycorticosterone
  • perivascular fibrosis
  • RU 486, interstitial fibrosis
  • salt

Cite this