Adoptive T cell immunotherapy for treatment of ganciclovir-resistant cytomegalovirus disease in a renal transplant recipient

N. Macesic; D. Langsford; K. Nicholls; P. Hughes; D. J. Gottlieb; L. Clancy; E. Blyth; K. Micklethwaite; B. Withers; S. Majumdar; S. Fleming; J. Sasadeusz

doi:10.1111/ajt.13023

Adoptive T cell immunotherapy for treatment of ganciclovir-resistant cytomegalovirus disease in a renal transplant recipient

N. Macesic, D. Langsford, K. Nicholls, P. Hughes, D. J. Gottlieb, L. Clancy, E. Blyth, K. Micklethwaite, B. Withers, S. Majumdar, S. Fleming, J. Sasadeusz

Research output: Contribution to journal › Article › Other › peer-review

54 Citations (Scopus)

Abstract

Cytomegalovirus (CMV) is a significant cause of morbidity, mortality and graft loss in solid organ transplantation (SOT). Treatment options for ganciclovir-resistant CMV are limited. We describe a case of ganciclovir-resistant CMV disease in a renal transplant recipient manifested by thrombotic microangiopathy-associated glomerulopathy. Adoptive T cell immunotherapy using CMV-specific T cells from a donor bank was used as salvage therapy. This report is a proof-of-concept of the clinical and logistical feasibility of this therapy in SOT recipients.

Original language	English
Pages (from-to)	827-832
Number of pages	6
Journal	American Journal of Transplantation
Volume	15
Issue number	3
DOIs	https://doi.org/10.1111/ajt.13023
Publication status	Published - 1 Mar 2015
Externally published	Yes

Keywords

antibiotic drug resistance
antibiotic: antiviral-ganciclovir/valganciclovir
clinical research/practice
infection and infectious agents
infectious disease
kidney transplantation/nephrology
viral: Cytomegalovirus (CMV)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/ajt.13023

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Macesic, N., Langsford, D., Nicholls, K., Hughes, P., Gottlieb, D. J., Clancy, L., Blyth, E., Micklethwaite, K., Withers, B., Majumdar, S., Fleming, S., & Sasadeusz, J. (2015). Adoptive T cell immunotherapy for treatment of ganciclovir-resistant cytomegalovirus disease in a renal transplant recipient. American Journal of Transplantation, 15(3), 827-832. https://doi.org/10.1111/ajt.13023

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abstract = "Cytomegalovirus (CMV) is a significant cause of morbidity, mortality and graft loss in solid organ transplantation (SOT). Treatment options for ganciclovir-resistant CMV are limited. We describe a case of ganciclovir-resistant CMV disease in a renal transplant recipient manifested by thrombotic microangiopathy-associated glomerulopathy. Adoptive T cell immunotherapy using CMV-specific T cells from a donor bank was used as salvage therapy. This report is a proof-of-concept of the clinical and logistical feasibility of this therapy in SOT recipients.",

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Macesic, N, Langsford, D, Nicholls, K, Hughes, P, Gottlieb, DJ, Clancy, L, Blyth, E, Micklethwaite, K, Withers, B, Majumdar, S, Fleming, S & Sasadeusz, J 2015, 'Adoptive T cell immunotherapy for treatment of ganciclovir-resistant cytomegalovirus disease in a renal transplant recipient', American Journal of Transplantation, vol. 15, no. 3, pp. 827-832. https://doi.org/10.1111/ajt.13023

TY - JOUR

T1 - Adoptive T cell immunotherapy for treatment of ganciclovir-resistant cytomegalovirus disease in a renal transplant recipient

AU - Macesic, N.

AU - Langsford, D.

AU - Nicholls, K.

AU - Hughes, P.

AU - Gottlieb, D. J.

AU - Clancy, L.

AU - Blyth, E.

AU - Micklethwaite, K.

AU - Withers, B.

AU - Majumdar, S.

AU - Fleming, S.

AU - Sasadeusz, J.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Cytomegalovirus (CMV) is a significant cause of morbidity, mortality and graft loss in solid organ transplantation (SOT). Treatment options for ganciclovir-resistant CMV are limited. We describe a case of ganciclovir-resistant CMV disease in a renal transplant recipient manifested by thrombotic microangiopathy-associated glomerulopathy. Adoptive T cell immunotherapy using CMV-specific T cells from a donor bank was used as salvage therapy. This report is a proof-of-concept of the clinical and logistical feasibility of this therapy in SOT recipients.

AB - Cytomegalovirus (CMV) is a significant cause of morbidity, mortality and graft loss in solid organ transplantation (SOT). Treatment options for ganciclovir-resistant CMV are limited. We describe a case of ganciclovir-resistant CMV disease in a renal transplant recipient manifested by thrombotic microangiopathy-associated glomerulopathy. Adoptive T cell immunotherapy using CMV-specific T cells from a donor bank was used as salvage therapy. This report is a proof-of-concept of the clinical and logistical feasibility of this therapy in SOT recipients.

KW - antibiotic drug resistance

KW - antibiotic: antiviral-ganciclovir/valganciclovir

KW - clinical research/practice

KW - infection and infectious agents

KW - infectious disease

KW - kidney transplantation/nephrology

KW - viral: Cytomegalovirus (CMV)

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U2 - 10.1111/ajt.13023

DO - 10.1111/ajt.13023

M3 - Article

C2 - 25648555

AN - SCOPUS:84923281820

SN - 1600-6135

VL - 15

SP - 827

EP - 832

JO - American Journal of Transplantation

JF - American Journal of Transplantation

IS - 3

ER -

Adoptive T cell immunotherapy for treatment of ganciclovir-resistant cytomegalovirus disease in a renal transplant recipient

Abstract

Keywords

UN SDGs

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