Adolescent impulsivity phenotypes characterized by distinct brain networks

Robert Whelan, Patricia J Conrod, Jean-Baptiste Poline, Anbarasu Lourdusamy, Tobias Banaschewski, Gareth J Barker, Mark Andrew Bellgrove, Christian Buchel, Mark Byrne, Tarrant Cummins, Mira Fauth-Buhler, Herta Flor, Jurgen Gallinat, Andreas Heinz, Bernd Ittermann, Karl Mann, Jean Luc Martinot, Edmund Lalor, Mark G Lathrop, Eva LothFrauke Nees, Tomas Paus, Marcella Rietschel, Michael N Smolka, Rainer Spanagel, David N Stephens, Maren Struve, Benjamin Thyreau, Sabine Vollstaedt-Klein, Trevor W Robbins, Gunter Schumann, Hugh Garavan

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263 Citations (Scopus)

Abstract

The impulsive behavior that is often characteristic of adolescence may reflect underlying neurodevelopmental processes. Moreover, impulsivity is a multi-dimensional construct, and it is plausible that distinct brain networks contribute to its different cognitive, clinical and behavioral aspects. As these networks have not yet been described, we identified distinct cortical and subcortical networks underlying successful inhibitions and inhibition failures in a large sample (n = 1,896) of 14-year-old adolescents. Different networks were associated with drug use (n = 1,593) and attention-deficit hyperactivity disorder symptoms (n = 342). Hypofunctioning of a specific orbitofrontal cortical network was associated with likelihood of initiating drug use in early adolescence. Right inferior frontal activity was related to the speed of the inhibition process (n = 826) and use of illegal substances and associated with genetic variation in a norepinephrine transporter gene (n = 819). Our results indicate that both neural endophenotypes and genetic variation give rise to the various manifestations of impulsive behavior.
Original languageEnglish
Pages (from-to)920 - 925
Number of pages6
JournalNature Neuroscience
Volume15
Issue number6
DOIs
Publication statusPublished - 2012
Externally publishedYes

Cite this

Whelan, R., Conrod, P. J., Poline, J-B., Lourdusamy, A., Banaschewski, T., Barker, G. J., Bellgrove, M. A., Buchel, C., Byrne, M., Cummins, T., Fauth-Buhler, M., Flor, H., Gallinat, J., Heinz, A., Ittermann, B., Mann, K., Martinot, J. L., Lalor, E., Lathrop, M. G., ... Garavan, H. (2012). Adolescent impulsivity phenotypes characterized by distinct brain networks. Nature Neuroscience, 15(6), 920 - 925. https://doi.org/10.1038/nn.3092