Adolescent cannabis use: What is the evidence for functional brain alteration?

Valentina Lorenzetti, Silvia Alonso-Lana, George J. Youssef, Antonio Verdejo-Garcia, Chao Suo, Janna Cousijn, Michael J Takagi, Murat Yücel, Nadia Solowij

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Background: Cannabis use typically commences during adolescence, a period during which the brain undergoes profound remodeling in areas that are high in cannabinoid receptors and that mediate cognitive control and emotion regulation. It is therefore important to determine the impact of adolescent cannabis use on brain function. Objective: We investigate the impact of adolescent cannabis use on brain function by reviewing the functional magnetic resonance imaging studies in adolescent samples. Method: We systematically reviewed the literature and identified 13 functional neuroimaging studies in adolescent cannabis users (aged 13 to 18 years) performing working memory, inhibition and reward processing tasks. Results: The majority of the studies found altered brain function, but intact behavioural task performance in adolescent cannabis users versus controls. The most consistently reported differences were in the frontal-parietal network, which mediates cognitive control. Heavier use was associated with abnormal brain function in most samples. A minority of studies controlled for the influence of confounders that can also undermine brain function, such as tobacco and alcohol use, psychopathology symptoms, family history of psychiatric disorders and substance use. Conclusion: Emerging evidence shows abnormal frontal-parietal network activity in adolescent cannabis users, particularly in heavier users. Brain functional alterations may reflect a compensatory neural mechanism that enables normal behavioural performance. It remains unclear if cannabis exposure drives these alterations, as substance use and mental health confounders have not been systematically examined.

Original languageEnglish
Pages (from-to)6353-6365
Number of pages13
JournalCurrent Pharmaceutical Design
Volume22
Issue number42
DOIs
Publication statusPublished - 1 Nov 2016

Keywords

  • Adolescence
  • Brain
  • Cannabis
  • Frontal cortex
  • Functional neuroimaging
  • Hyperactivity
  • Parietal cortex

Cite this

Lorenzetti, Valentina ; Alonso-Lana, Silvia ; Youssef, George J. ; Verdejo-Garcia, Antonio ; Suo, Chao ; Cousijn, Janna ; Takagi, Michael J ; Yücel, Murat ; Solowij, Nadia. / Adolescent cannabis use : What is the evidence for functional brain alteration?. In: Current Pharmaceutical Design. 2016 ; Vol. 22, No. 42. pp. 6353-6365.
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abstract = "Background: Cannabis use typically commences during adolescence, a period during which the brain undergoes profound remodeling in areas that are high in cannabinoid receptors and that mediate cognitive control and emotion regulation. It is therefore important to determine the impact of adolescent cannabis use on brain function. Objective: We investigate the impact of adolescent cannabis use on brain function by reviewing the functional magnetic resonance imaging studies in adolescent samples. Method: We systematically reviewed the literature and identified 13 functional neuroimaging studies in adolescent cannabis users (aged 13 to 18 years) performing working memory, inhibition and reward processing tasks. Results: The majority of the studies found altered brain function, but intact behavioural task performance in adolescent cannabis users versus controls. The most consistently reported differences were in the frontal-parietal network, which mediates cognitive control. Heavier use was associated with abnormal brain function in most samples. A minority of studies controlled for the influence of confounders that can also undermine brain function, such as tobacco and alcohol use, psychopathology symptoms, family history of psychiatric disorders and substance use. Conclusion: Emerging evidence shows abnormal frontal-parietal network activity in adolescent cannabis users, particularly in heavier users. Brain functional alterations may reflect a compensatory neural mechanism that enables normal behavioural performance. It remains unclear if cannabis exposure drives these alterations, as substance use and mental health confounders have not been systematically examined.",
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Lorenzetti, V, Alonso-Lana, S, Youssef, GJ, Verdejo-Garcia, A, Suo, C, Cousijn, J, Takagi, MJ, Yücel, M & Solowij, N 2016, 'Adolescent cannabis use: What is the evidence for functional brain alteration?' Current Pharmaceutical Design, vol. 22, no. 42, pp. 6353-6365. https://doi.org/10.2174/1381612822666160805155922

Adolescent cannabis use : What is the evidence for functional brain alteration? / Lorenzetti, Valentina; Alonso-Lana, Silvia; Youssef, George J.; Verdejo-Garcia, Antonio; Suo, Chao; Cousijn, Janna; Takagi, Michael J; Yücel, Murat; Solowij, Nadia.

In: Current Pharmaceutical Design, Vol. 22, No. 42, 01.11.2016, p. 6353-6365.

Research output: Contribution to journalReview ArticleResearchpeer-review

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T2 - What is the evidence for functional brain alteration?

AU - Lorenzetti, Valentina

AU - Alonso-Lana, Silvia

AU - Youssef, George J.

AU - Verdejo-Garcia, Antonio

AU - Suo, Chao

AU - Cousijn, Janna

AU - Takagi, Michael J

AU - Yücel, Murat

AU - Solowij, Nadia

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N2 - Background: Cannabis use typically commences during adolescence, a period during which the brain undergoes profound remodeling in areas that are high in cannabinoid receptors and that mediate cognitive control and emotion regulation. It is therefore important to determine the impact of adolescent cannabis use on brain function. Objective: We investigate the impact of adolescent cannabis use on brain function by reviewing the functional magnetic resonance imaging studies in adolescent samples. Method: We systematically reviewed the literature and identified 13 functional neuroimaging studies in adolescent cannabis users (aged 13 to 18 years) performing working memory, inhibition and reward processing tasks. Results: The majority of the studies found altered brain function, but intact behavioural task performance in adolescent cannabis users versus controls. The most consistently reported differences were in the frontal-parietal network, which mediates cognitive control. Heavier use was associated with abnormal brain function in most samples. A minority of studies controlled for the influence of confounders that can also undermine brain function, such as tobacco and alcohol use, psychopathology symptoms, family history of psychiatric disorders and substance use. Conclusion: Emerging evidence shows abnormal frontal-parietal network activity in adolescent cannabis users, particularly in heavier users. Brain functional alterations may reflect a compensatory neural mechanism that enables normal behavioural performance. It remains unclear if cannabis exposure drives these alterations, as substance use and mental health confounders have not been systematically examined.

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