Admixture into and within sub-Saharan Africa

George B.J. Busby; Gavin Band; Quang Si Le; Muminatou Jallow; Edith Bougama; Valentina D. Mangano; Anthony Enimil; Tobias Apinjoh; Carolyne M. Ndila; Alphaxard Manjurano; Vysaul Nyirongo; Ogobara Doumba; Kirk A. Rockett; Dominic P Kwiatkowski; Chris C.A. Spencer; Malaria Genomic Epidemiology Network

doi:10.7554/eLife.15266.001

Admixture into and within sub-Saharan Africa

George B.J. Busby, Gavin Band, Quang Si Le, Muminatou Jallow, Edith Bougama, Valentina D. Mangano, Anthony Enimil, Tobias Apinjoh, Carolyne M. Ndila, Alphaxard Manjurano, Vysaul Nyirongo, Ogobara Doumba, Kirk A. Rockett, Dominic P Kwiatkowski, Chris C.A. Spencer, Malaria Genomic Epidemiology Network

Research output: Contribution to journal › Article › Research › peer-review

46 Citations (Scopus)

Abstract

Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology.

Original language	English
Article number	e15266
Number of pages	44
Journal	eLife
Volume	5
Issue number	JUN2016
DOIs	https://doi.org/10.7554/eLife.15266.001
Publication status	Published - 21 Jun 2016
Externally published	Yes

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10.7554/eLife.15266.001

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Busby, G. B. J., Band, G., Le, Q. S., Jallow, M., Bougama, E., Mangano, V. D., Enimil, A., Apinjoh, T., Ndila, C. M., Manjurano, A., Nyirongo, V., Doumba, O., Rockett, K. A., Kwiatkowski, D. P., Spencer, C. C. A., & Malaria Genomic Epidemiology Network (2016). Admixture into and within sub-Saharan Africa. eLife, 5(JUN2016), Article e15266. https://doi.org/10.7554/eLife.15266.001

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title = "Admixture into and within sub-Saharan Africa",

abstract = "Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology.",

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year = "2016",

month = jun,

day = "21",

doi = "10.7554/eLife.15266.001",

language = "English",

volume = "5",

journal = "eLife",

issn = "2050-084X",

publisher = "eLife Sciences Organisation, Ltd.",

number = "JUN2016",

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AU - Busby, George B.J.

AU - Band, Gavin

AU - Le, Quang Si

AU - Jallow, Muminatou

AU - Bougama, Edith

AU - Mangano, Valentina D.

AU - Amenga-Etego, Lucas N.

AU - Enimil, Anthony

AU - Apinjoh, Tobias

AU - Ndila, Carolyne M.

AU - Manjurano, Alphaxard

AU - Nyirongo, Vysaul

AU - Doumba, Ogobara

AU - Rockett, Kirk A.

AU - Kwiatkowski, Dominic P

AU - Spencer, Chris C.A.

AU - Malaria Genomic Epidemiology Network

AU - Vanderwal, Aaron

AU - Elzein, Abier

AU - Nyika, Aceme

AU - Mendy, Alieu

AU - Miles, Alistair

AU - Diss, Andrea

AU - Kerasidou, Angeliki

AU - Green, Angie

AU - Jeffreys, Anna E.

AU - Macinnis, Bronwyn

AU - Hughes, Catherine

AU - Moyes, Catherine L.

AU - Hubbart, Christina

AU - Malangone, Cinzia

AU - Potter, Claire

AU - Mead, Daniel

AU - Barnwell, David

AU - Jyothi, Dushyanth

AU - Drury, Eleanor

AU - Somaskantharajah, Elilan

AU - Hilton, Eliza

AU - Leffler, Ellen

AU - Maslen, Gareth

AU - Busby, George

AU - Clarke, Geraldine M.

AU - Ragoussis, Ioannis

AU - Garcia, Jacob Almagro

AU - Rogers, Jane

AU - deVries, Jantina

AU - Shelton, Jennifer

AU - Ragoussis, Jiannis

AU - Stalker, Jim

AU - Rodford, Joanne

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AU - Evans, Julie

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AU - Stevens, Marryat

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AU - Hennsman, Meike

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AU - Seplúveda, Nuno

AU - Cook, Olivia

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AU - Watson, Renee

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AU - Risley, Paul

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AU - Ebonyi, Augustine

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AU - Taal, Bintou

AU - Casals-Pascual, Climent

AU - Conway, David J

AU - Onykwelu, Emmanuel

AU - Sisay-Joof, Fatoumatta

AU - Sirugo, Giorgio

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AU - Njie, Haddy

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AU - Abubakar, Ismaela

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AU - Jaiteh, Jula

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AU - Jammeh, Kebba

AU - Sabally-Ceesay, Kumba

AU - Manneh, Lamin

AU - Camara, Landing

AU - Yamoah, Lawrence

AU - Njie, Madi

AU - Pinder, Margaret

AU - Jallow, Mariatou

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AU - Jasseh, Momodou

AU - Keita, Momodou Lamin

AU - Saidy-Khan, Momodou

AU - Ceesay, Ndey

AU - Rasheed, Oba

AU - Ceesay, Pa Lamin

AU - Esangbedo, Pamela

AU - Cole-Ceesay, Ramou

AU - Olaosebikan, Rasaq R

AU - Correa, Simon

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AU - Diakite, Mahamadou

AU - Konate, Amadou T.

AU - Modiano, David

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AU - Mensah, Nathan

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AU - Sambian, David

AU - Asafo-Agyei, Emmanuel

AU - Sylverken, Justice

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AU - Agbenyega, Tsiri

AU - Orimadegun, Adebola E.

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AU - Oni, Olajumoke

AU - Omotade, Olayemi O.

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AU - Olaniyan, Subulade

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AU - Achidi, Eric Akum

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AU - Ibrahim, Muntaser

AU - Kokwaro, Gilbert

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AU - Macharia, Alexander

AU - Newton, Charles

AU - Opi, Daniel H.

AU - Kamuya, Dorcas

AU - Bauni, Evasius

AU - Marsh, Kevin

AU - Peshu, Norbert

AU - Molyneux, Sassy

AU - Uyoga, Sophie M

AU - Williams, Thomas N.

AU - Marsh, Vicki

AU - Nadjm, Behzad

AU - Maxwell, Caroline

AU - Drakeley, Chris J

AU - Riley, Eleanor

AU - Mtei, Frank

AU - Mtove, George

AU - Wangai, Hannah

AU - Reyburn, Hugh

AU - Joseph, Sarah

AU - Ishengoma, Deus

AU - Lemnge, Martha

AU - Mutabingwa, Theonest

AU - Makani, Julie

AU - Cox, Sharon

AU - Phiri, Ajib

AU - Munthali, Annie

AU - Kachala, David

AU - Njiragoma, Labes

AU - Molyneux, Malcolm E

AU - Moore, Mike

AU - Ntunthama, Neema

AU - Pensulo, Paul

AU - Taylor, Terrie

AU - Carter, Richard

AU - Fernando, Deepika

AU - Karunaweera, Nadira

AU - Dewasurendra, Rajika

AU - Simmons, Cameron P.

PY - 2016/6/21

Y1 - 2016/6/21

N2 - Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology.

AB - Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology.

UR - http://www.scopus.com/inward/record.url?scp=84975491862&partnerID=8YFLogxK

U2 - 10.7554/eLife.15266.001

DO - 10.7554/eLife.15266.001

M3 - Article

SN - 2050-084X

VL - 5

JO - eLife

JF - eLife

IS - JUN2016

M1 - e15266

ER -

Admixture into and within sub-Saharan Africa

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