Administration of gonadotropins for superovulation in mice

Richard Behringer, Marina Gertsenstein, Kristina Vintersten Nagy, Andras Nagy

Research output: Contribution to journalArticleOtherpeer-review

7 Citations (Scopus)

Abstract

For experiments that require large numbers of preimplantation mouse embryos, such as microinjection of zygotes, gonadotropins are administered to females before mating to increase the number of oocytes that are ovulated (i.e., to induce superovulation). Pregnant mare serum gonadotropin (PMSG) is used to mimic the oocyte maturation effect of the endogenous follicle-stimulating hormone (FSH), and human chorionic gonadotropin (hCG) is used to mimic the ovulation induction effect of luteinizing hormone (LH).

Original languageEnglish
Pages (from-to)24-27
Number of pages4
JournalCold Spring Harbor Protocols
Volume2018
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018

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