Adjuvant Therapies in Venous Leg Ulcer Management: A Scoping Review

Victoria Team, Peter G. Chandler, Carolina D. Weller

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Compression therapy is the current evidence-based approach to manage venous leg ulcers (VLU), however adherence is a major barrier to successful treatment. Combination approaches may relieve the burden of treatment by shortening the time to ulcer healing. This scoping review conducted by Australian researchers aimed to establish the evidence of effectiveness of various adjuvant methods on wound healing and recurrence. Randomised Controlled Trials (RCTs), and Systematic Reviews (SR) and Meta-Analyses (MA) on VLU management approaches published from January 2015 to December 2018 were included in this review. The articles included in the scoping review were grouped according with the management approaches, including 1) pharmaceutical interventions, 2) surgical interventions, 3) topical agents, 4) the use of devices, and 5) other, such as physiotherapy and psychological interventions. Results of this coping review indicate that there is limited high-quality evidence of effectiveness in most adjuvant therapies on wound healing and recurrence. Given the low quality evidence observed in this scoping review for adjuvant treatments, the implication for practice is that current management guidelines be followed. Further rigorous studies have the potential to produce better quality evidence. Quality of evidence can be improved by ensuring large sample sizes of a single etiology wounds, standardising reporting outcomes, and maintaining detailed and evidence-based protocols in physiological or psychological interventions.
Original languageEnglish
JournalWound Repair and Regeneration
DOIs
Publication statusAccepted/In press - 26 Apr 2019

Keywords

  • adjuvant therapies
  • compression
  • evidence-based practice
  • scoping review

Cite this

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title = "Adjuvant Therapies in Venous Leg Ulcer Management: A Scoping Review",
abstract = "Compression therapy is the current evidence-based approach to manage venous leg ulcers (VLU), however adherence is a major barrier to successful treatment. Combination approaches may relieve the burden of treatment by shortening the time to ulcer healing. This scoping review conducted by Australian researchers aimed to establish the evidence of effectiveness of various adjuvant methods on wound healing and recurrence. Randomised Controlled Trials (RCTs), and Systematic Reviews (SR) and Meta-Analyses (MA) on VLU management approaches published from January 2015 to December 2018 were included in this review. The articles included in the scoping review were grouped according with the management approaches, including 1) pharmaceutical interventions, 2) surgical interventions, 3) topical agents, 4) the use of devices, and 5) other, such as physiotherapy and psychological interventions. Results of this coping review indicate that there is limited high-quality evidence of effectiveness in most adjuvant therapies on wound healing and recurrence. Given the low quality evidence observed in this scoping review for adjuvant treatments, the implication for practice is that current management guidelines be followed. Further rigorous studies have the potential to produce better quality evidence. Quality of evidence can be improved by ensuring large sample sizes of a single etiology wounds, standardising reporting outcomes, and maintaining detailed and evidence-based protocols in physiological or psychological interventions.",
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year = "2019",
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Adjuvant Therapies in Venous Leg Ulcer Management : A Scoping Review. / Team, Victoria; Chandler, Peter G.; Weller, Carolina D.

In: Wound Repair and Regeneration, 26.04.2019.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Adjuvant Therapies in Venous Leg Ulcer Management

T2 - A Scoping Review

AU - Team, Victoria

AU - Chandler, Peter G.

AU - Weller, Carolina D.

PY - 2019/4/26

Y1 - 2019/4/26

N2 - Compression therapy is the current evidence-based approach to manage venous leg ulcers (VLU), however adherence is a major barrier to successful treatment. Combination approaches may relieve the burden of treatment by shortening the time to ulcer healing. This scoping review conducted by Australian researchers aimed to establish the evidence of effectiveness of various adjuvant methods on wound healing and recurrence. Randomised Controlled Trials (RCTs), and Systematic Reviews (SR) and Meta-Analyses (MA) on VLU management approaches published from January 2015 to December 2018 were included in this review. The articles included in the scoping review were grouped according with the management approaches, including 1) pharmaceutical interventions, 2) surgical interventions, 3) topical agents, 4) the use of devices, and 5) other, such as physiotherapy and psychological interventions. Results of this coping review indicate that there is limited high-quality evidence of effectiveness in most adjuvant therapies on wound healing and recurrence. Given the low quality evidence observed in this scoping review for adjuvant treatments, the implication for practice is that current management guidelines be followed. Further rigorous studies have the potential to produce better quality evidence. Quality of evidence can be improved by ensuring large sample sizes of a single etiology wounds, standardising reporting outcomes, and maintaining detailed and evidence-based protocols in physiological or psychological interventions.

AB - Compression therapy is the current evidence-based approach to manage venous leg ulcers (VLU), however adherence is a major barrier to successful treatment. Combination approaches may relieve the burden of treatment by shortening the time to ulcer healing. This scoping review conducted by Australian researchers aimed to establish the evidence of effectiveness of various adjuvant methods on wound healing and recurrence. Randomised Controlled Trials (RCTs), and Systematic Reviews (SR) and Meta-Analyses (MA) on VLU management approaches published from January 2015 to December 2018 were included in this review. The articles included in the scoping review were grouped according with the management approaches, including 1) pharmaceutical interventions, 2) surgical interventions, 3) topical agents, 4) the use of devices, and 5) other, such as physiotherapy and psychological interventions. Results of this coping review indicate that there is limited high-quality evidence of effectiveness in most adjuvant therapies on wound healing and recurrence. Given the low quality evidence observed in this scoping review for adjuvant treatments, the implication for practice is that current management guidelines be followed. Further rigorous studies have the potential to produce better quality evidence. Quality of evidence can be improved by ensuring large sample sizes of a single etiology wounds, standardising reporting outcomes, and maintaining detailed and evidence-based protocols in physiological or psychological interventions.

KW - adjuvant therapies

KW - compression

KW - evidence-based practice

KW - scoping review

U2 - 10.1111/wrr.12724

DO - 10.1111/wrr.12724

M3 - Article

JO - Wound Repair and Regeneration

JF - Wound Repair and Regeneration

SN - 1067-1927

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