TY - JOUR
T1 - Adipose-derived stem cells
T2 - Fatty potentials for therapy
AU - Ong, Wee Kiat
AU - Sugii, Shigeki
N1 - Funding Information:
We would like to apologize those authors whose important work could not be cited in this mini-review due to the limitation of reference number. We thank Dr. W. Han and members of Laboratory of Metabolic Medicine (LMM) for supporting our research activities. LMM is sponsored by an intramural funding from Biomedical Research Council of Agency for Science, Technology and Research (A*STAR) .
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2013/6
Y1 - 2013/6
N2 - Adipose-derived stem cells (ASCs) are the mesenchymal stem cell (MSC) population found in the stromal-vascular fraction (SVF) of fat tissue. White adipose tissue (WAT), with well-established roles in lipid storage and adipokine secretion, is advantageous over bone marrow as the source of MSCs due to relative abundance and ease of isolation of the tissue. ASCs reside perivascularly within WAT and physiologically undergo adipogenesis to support WAT expansion in response to increased energy intake. Apart from adipogenesis, ASCs can be induced in vitro to differentiate into osteoblasts, chondroblasts, myocytes, neurons and other cell types. ASCs can also be reprogrammed to induced pluripotent stem (iPS) cells more efficiently than other cell types. ASCs are immunoprivileged cells and secrete immunomodulatory, angiogenic, anti-apoptotic and haematopoietic factors that facilitate tissue repair. The multi-lineage differentiation capacity, unique immunobiological properties and secretome of ASCs offer tremendous therapeutic potentials in regenerative medicine.
AB - Adipose-derived stem cells (ASCs) are the mesenchymal stem cell (MSC) population found in the stromal-vascular fraction (SVF) of fat tissue. White adipose tissue (WAT), with well-established roles in lipid storage and adipokine secretion, is advantageous over bone marrow as the source of MSCs due to relative abundance and ease of isolation of the tissue. ASCs reside perivascularly within WAT and physiologically undergo adipogenesis to support WAT expansion in response to increased energy intake. Apart from adipogenesis, ASCs can be induced in vitro to differentiate into osteoblasts, chondroblasts, myocytes, neurons and other cell types. ASCs can also be reprogrammed to induced pluripotent stem (iPS) cells more efficiently than other cell types. ASCs are immunoprivileged cells and secrete immunomodulatory, angiogenic, anti-apoptotic and haematopoietic factors that facilitate tissue repair. The multi-lineage differentiation capacity, unique immunobiological properties and secretome of ASCs offer tremendous therapeutic potentials in regenerative medicine.
KW - Adipose-derived stromal cells
KW - Fat development and origin
KW - iPS cells/iPSCs
KW - Preadipocyte/adipocytic progenitor
KW - Regenerative therapies
UR - http://www.scopus.com/inward/record.url?scp=84876464760&partnerID=8YFLogxK
U2 - 10.1016/j.biocel.2013.02.013
DO - 10.1016/j.biocel.2013.02.013
M3 - Short Survey
AN - SCOPUS:84876464760
SN - 1357-2725
VL - 45
SP - 1083
EP - 1086
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
IS - 6
ER -