Adiponectin, an anti-carcinogenic hormone? A systematic review on breast, colorectal, liver and prostate cancer

Stephane Perrier, Thierry Jarde

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Abstract

Adiponectin is an adipose tissue-derived hormone, expressed almost exclusively in adipose tissue, with significant antidiabetic, anti-atherosclerotic, anti-inflammatory and anti-proliferative properties. The anti-carcinogenic effects of adiponectin result from two main mechanisms: a modulation in the signaling pathways involved in proliferation process and a subtle regulation of the apoptotic response. In this review, we present recent findings on the association of adiponectin with the risk of several malignancies (breast, colorectal, liver and prostate cancers), as well as data on underlying molecular mechanisms by which adiponectin plays a substantial role in cancer pathogenesis.
Original languageEnglish
Pages (from-to)5501 - 5512
Number of pages12
JournalCurrent Medicinal Chemistry
Volume19
Issue number32
DOIs
Publication statusPublished - 2012
Externally publishedYes

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