Adhesion and dispersion of salmeterol xinafoate from lactose interactive mixtures for inhalation - can surface roughness of carriers determine performance

Mohd Nazrul Islam, Peter James Stewart, Ian Clair Larson, Patrick Hartley

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review


The objective was to understand the influence of the surface roughness of lactose carriers on the adhesion and dispersion of salmeterol xinafoate (SX) from interactive mixtures. The surface roughness of lactose carriers was determined by confocal microscopy. Particle images and adhesion forces between SX and lactose particles were determined by Atomic Force Microscopy. The dispersion of SX (2.5 ) from interactive mixtures with lactose was determined using a twin-stage impiger (TSI) with a RotahalerA? at an airflow rate of 60L/min. SX was analysed using a validated HPLC assay. The RMS Rq of lactose carriers ranged from 0.93-2.84A?m, the Fine Particle Fraction (FPF) of SX ranged between 4 and 24 percent and average adhesion force between a SX and lactose particles ranged between the RMS Rq of lactose carriers and either the FPF of SX for the interactive mixtures or the adhesion force of a SX on the lactose particles; however, the presence of fine lactose associated with the carrier surface increased the FPF of SX. Dispersion through direct SX detachment from the carrier surface was not consistent with the poor correlations described and was more likely to occur through complex particulate interactions involving fine lactose.
Original languageEnglish
Title of host publicationCHEMECA 2009
EditorsT Heyns, M Ang, C Butler, P Hay, R Kelson, J Langford, Y K Leong, P McEwen, D Montgomery, P Snowsill, M Tade
Place of PublicationAustralia
PublisherEngineers Australia
Pages1 - 10
Number of pages10
ISBN (Print)9780858259225
Publication statusPublished - 2009
EventChemeca: Australasian Conference on Chemical Engineering 2009 - Perth, Australia
Duration: 27 Sept 200930 Sept 2009
Conference number: 37th


ConferenceChemeca: Australasian Conference on Chemical Engineering 2009
Abbreviated titleCHEMECA 2009

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