Adhesion and dispersion of salmeterol xinafoate from lactose interactive mixtures for inhalation - can surface roughness of carriers determine performance

Mohd Nazrul Islam, Peter James Stewart, Ian Clair Larson, Patrick Hartley

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Abstract

The objective was to understand the influence of the surface roughness of lactose carriers on the adhesion and dispersion of salmeterol xinafoate (SX) from interactive mixtures. The surface roughness of lactose carriers was determined by confocal microscopy. Particle images and adhesion forces between SX and lactose particles were determined by Atomic Force Microscopy. The dispersion of SX (2.5 ) from interactive mixtures with lactose was determined using a twin-stage impiger (TSI) with a RotahalerA? at an airflow rate of 60L/min. SX was analysed using a validated HPLC assay. The RMS Rq of lactose carriers ranged from 0.93-2.84A?m, the Fine Particle Fraction (FPF) of SX ranged between 4 and 24 percent and average adhesion force between a SX and lactose particles ranged between the RMS Rq of lactose carriers and either the FPF of SX for the interactive mixtures or the adhesion force of a SX on the lactose particles; however, the presence of fine lactose associated with the carrier surface increased the FPF of SX. Dispersion through direct SX detachment from the carrier surface was not consistent with the poor correlations described and was more likely to occur through complex particulate interactions involving fine lactose.
Original languageEnglish
Title of host publicationCHEMECA 2009
EditorsT Heyns, M Ang, C Butler, P Hay, R Kelson, J Langford, Y K Leong, P McEwen, D Montgomery, P Snowsill, M Tade
Place of PublicationAustralia
PublisherEngineers Australia
Pages1 - 10
Number of pages10
ISBN (Print)9780858259225
Publication statusPublished - 2009
EventChemeca: Australasian Conference on Chemical Engineering 2009 - Perth, W.A., Perth, Australia
Duration: 1 Jan 2009 → …

Conference

ConferenceChemeca: Australasian Conference on Chemical Engineering 2009
CountryAustralia
CityPerth
Period1/01/09 → …

Cite this

Islam, M. N., Stewart, P. J., Larson, I. C., & Hartley, P. (2009). Adhesion and dispersion of salmeterol xinafoate from lactose interactive mixtures for inhalation - can surface roughness of carriers determine performance. In T. Heyns, M. Ang, C. Butler, P. Hay, R. Kelson, J. Langford, Y. K. Leong, P. McEwen, D. Montgomery, P. Snowsill, ... M. Tade (Eds.), CHEMECA 2009 (pp. 1 - 10). Australia: Engineers Australia.
Islam, Mohd Nazrul ; Stewart, Peter James ; Larson, Ian Clair ; Hartley, Patrick. / Adhesion and dispersion of salmeterol xinafoate from lactose interactive mixtures for inhalation - can surface roughness of carriers determine performance. CHEMECA 2009. editor / T Heyns ; M Ang ; C Butler ; P Hay ; R Kelson ; J Langford ; Y K Leong ; P McEwen ; D Montgomery ; P Snowsill ; M Tade. Australia : Engineers Australia, 2009. pp. 1 - 10
@inproceedings{61520d28c4a44d22b18b608dbf88adcd,
title = "Adhesion and dispersion of salmeterol xinafoate from lactose interactive mixtures for inhalation - can surface roughness of carriers determine performance",
abstract = "The objective was to understand the influence of the surface roughness of lactose carriers on the adhesion and dispersion of salmeterol xinafoate (SX) from interactive mixtures. The surface roughness of lactose carriers was determined by confocal microscopy. Particle images and adhesion forces between SX and lactose particles were determined by Atomic Force Microscopy. The dispersion of SX (2.5 ) from interactive mixtures with lactose was determined using a twin-stage impiger (TSI) with a RotahalerA? at an airflow rate of 60L/min. SX was analysed using a validated HPLC assay. The RMS Rq of lactose carriers ranged from 0.93-2.84A?m, the Fine Particle Fraction (FPF) of SX ranged between 4 and 24 percent and average adhesion force between a SX and lactose particles ranged between the RMS Rq of lactose carriers and either the FPF of SX for the interactive mixtures or the adhesion force of a SX on the lactose particles; however, the presence of fine lactose associated with the carrier surface increased the FPF of SX. Dispersion through direct SX detachment from the carrier surface was not consistent with the poor correlations described and was more likely to occur through complex particulate interactions involving fine lactose.",
author = "Islam, {Mohd Nazrul} and Stewart, {Peter James} and Larson, {Ian Clair} and Patrick Hartley",
year = "2009",
language = "English",
isbn = "9780858259225",
pages = "1 -- 10",
editor = "T Heyns and M Ang and C Butler and P Hay and R Kelson and J Langford and Leong, {Y K} and P McEwen and D Montgomery and P Snowsill and M Tade",
booktitle = "CHEMECA 2009",
publisher = "Engineers Australia",

}

Islam, MN, Stewart, PJ, Larson, IC & Hartley, P 2009, Adhesion and dispersion of salmeterol xinafoate from lactose interactive mixtures for inhalation - can surface roughness of carriers determine performance. in T Heyns, M Ang, C Butler, P Hay, R Kelson, J Langford, YK Leong, P McEwen, D Montgomery, P Snowsill & M Tade (eds), CHEMECA 2009. Engineers Australia, Australia, pp. 1 - 10, Chemeca: Australasian Conference on Chemical Engineering 2009, Perth, Australia, 1/01/09.

Adhesion and dispersion of salmeterol xinafoate from lactose interactive mixtures for inhalation - can surface roughness of carriers determine performance. / Islam, Mohd Nazrul; Stewart, Peter James; Larson, Ian Clair; Hartley, Patrick.

CHEMECA 2009. ed. / T Heyns; M Ang; C Butler; P Hay; R Kelson; J Langford; Y K Leong; P McEwen; D Montgomery; P Snowsill; M Tade. Australia : Engineers Australia, 2009. p. 1 - 10.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

TY - GEN

T1 - Adhesion and dispersion of salmeterol xinafoate from lactose interactive mixtures for inhalation - can surface roughness of carriers determine performance

AU - Islam, Mohd Nazrul

AU - Stewart, Peter James

AU - Larson, Ian Clair

AU - Hartley, Patrick

PY - 2009

Y1 - 2009

N2 - The objective was to understand the influence of the surface roughness of lactose carriers on the adhesion and dispersion of salmeterol xinafoate (SX) from interactive mixtures. The surface roughness of lactose carriers was determined by confocal microscopy. Particle images and adhesion forces between SX and lactose particles were determined by Atomic Force Microscopy. The dispersion of SX (2.5 ) from interactive mixtures with lactose was determined using a twin-stage impiger (TSI) with a RotahalerA? at an airflow rate of 60L/min. SX was analysed using a validated HPLC assay. The RMS Rq of lactose carriers ranged from 0.93-2.84A?m, the Fine Particle Fraction (FPF) of SX ranged between 4 and 24 percent and average adhesion force between a SX and lactose particles ranged between the RMS Rq of lactose carriers and either the FPF of SX for the interactive mixtures or the adhesion force of a SX on the lactose particles; however, the presence of fine lactose associated with the carrier surface increased the FPF of SX. Dispersion through direct SX detachment from the carrier surface was not consistent with the poor correlations described and was more likely to occur through complex particulate interactions involving fine lactose.

AB - The objective was to understand the influence of the surface roughness of lactose carriers on the adhesion and dispersion of salmeterol xinafoate (SX) from interactive mixtures. The surface roughness of lactose carriers was determined by confocal microscopy. Particle images and adhesion forces between SX and lactose particles were determined by Atomic Force Microscopy. The dispersion of SX (2.5 ) from interactive mixtures with lactose was determined using a twin-stage impiger (TSI) with a RotahalerA? at an airflow rate of 60L/min. SX was analysed using a validated HPLC assay. The RMS Rq of lactose carriers ranged from 0.93-2.84A?m, the Fine Particle Fraction (FPF) of SX ranged between 4 and 24 percent and average adhesion force between a SX and lactose particles ranged between the RMS Rq of lactose carriers and either the FPF of SX for the interactive mixtures or the adhesion force of a SX on the lactose particles; however, the presence of fine lactose associated with the carrier surface increased the FPF of SX. Dispersion through direct SX detachment from the carrier surface was not consistent with the poor correlations described and was more likely to occur through complex particulate interactions involving fine lactose.

UR - http://www.icms.com.au/chemeca2009/abstract/49.asp (abstract of paper on CD of cionference proceedings)

M3 - Conference Paper

SN - 9780858259225

SP - 1

EP - 10

BT - CHEMECA 2009

A2 - Heyns, T

A2 - Ang, M

A2 - Butler, C

A2 - Hay, P

A2 - Kelson, R

A2 - Langford, J

A2 - Leong, Y K

A2 - McEwen, P

A2 - Montgomery, D

A2 - Snowsill, P

A2 - Tade, M

PB - Engineers Australia

CY - Australia

ER -

Islam MN, Stewart PJ, Larson IC, Hartley P. Adhesion and dispersion of salmeterol xinafoate from lactose interactive mixtures for inhalation - can surface roughness of carriers determine performance. In Heyns T, Ang M, Butler C, Hay P, Kelson R, Langford J, Leong YK, McEwen P, Montgomery D, Snowsill P, Tade M, editors, CHEMECA 2009. Australia: Engineers Australia. 2009. p. 1 - 10