Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study

Enrica Menditto, Elisio Costa, Luis Midão, Sinthia Bosnic-Anticevich, Ettore Novellino, Slawomir Bialek, Vitalis Briedis, Alpana Mair, Rojin Rajabian-Soderlund, Sylvie Arnavielhe, Anna Bedbrook, Wienczyslawa Czarlewski, Isabella Annesi-Maesano, Josep M. Anto, Philippe Devillier, Govert De Vries, Thomas Keil, Aziz Sheikh, Valentina Orlando, Désirée Larenas-Linnemann & 47 others Lorenzo Cecchi, Giulia De Feo, M. Illario, Cristiana Stellato, Joao Fonseca, Joao Malva, Mario Morais-Almeida, Ana Maria Pereira, Ana Maria Todo-Bom, Violeta Kvedariene, Arunas Valiulis, Karl Christian Bergmann, Ludger Klimek, Ralph Mösges, Oliver Pfaar, Torsten Zuberbier, Vicky Cardona, Joaquim Mullol, Nikos G. Papadopoulos, Emmanuel P. Prokopakis, Mike Bewick, Dermot Ryan, Regina E. Roller-Wirnsberger, Peter Valentin Tomazic, Alvaro A. Cruz, Piotr Kuna, Boleslaw Samolinski, Wytske J. Fokkens, Sietze Reitsma, Isabelle Bosse, Jean François Fontaine, Daniel Laune, Tari Haahtela, Sanna Toppila-Salmi, Claus Bachert, Peter W. Hellings, Erik Melén, Magnus Wickman, Carsten Bindslev-Jensen, Esben Eller, Robyn E. O'Hehir, Cemal Cingi, Bilun Gemicioğlu, Omer Kalayci, Juan Carlos Ivancevich, Jean Bousquet, the MASK group

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

Background: Mobile technology may help to better understand the adherence to treatment. MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries. Objectives: To assess the adherence to treatment in allergic rhinitis patients using the Allergy Diary App. Methods: An observational cross-sectional study was carried out on all users who filled in the Allergy Diary from 1 January 2016 to 1 August 2017. Secondary adherence was assessed by using the modified Medication Possession Ratio (MPR) and the Proportion of days covered (PDC) approach. Results: A total of 12 143 users were registered. A total of 6 949 users reported at least one VAS data recording. Among them, 1 887 users reported ≥7 VAS data. About 1 195 subjects were included in the analysis of adherence. One hundred and thirty-six (11.28%) users were adherent (MPR ≥70% and PDC ≤1.25), 51 (4.23%) were partly adherent (MPR ≥70% and PDC = 1.50) and 176 (14.60%) were switchers. On the other hand, 832 (69.05%) users were non-adherent to medications (MPR <70%). Of those, the largest group was non-adherent to medications and the time interval was increased in 442 (36.68%) users. Conclusion and clinical relevance: Adherence to treatment is low. The relative efficacy of continuous vs on-demand treatment for allergic rhinitis symptoms is still a matter of debate. This study shows an approach for measuring retrospective adherence based on a mobile app. This also represents a novel approach for analysing medication-taking behaviour in a real-world setting.

Original languageEnglish
Pages (from-to)442-460
Number of pages19
JournalClinical and Experimental Allergy
Volume49
Issue number4
DOIs
Publication statusPublished - Apr 2019

Keywords

  • adherence
  • mHealth
  • mobile technology
  • observational study
  • rhinitis
  • treatment

Cite this

Menditto, E., Costa, E., Midão, L., Bosnic-Anticevich, S., Novellino, E., Bialek, S., ... the MASK group (2019). Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study. Clinical and Experimental Allergy, 49(4), 442-460. https://doi.org/10.1111/cea.13333
Menditto, Enrica ; Costa, Elisio ; Midão, Luis ; Bosnic-Anticevich, Sinthia ; Novellino, Ettore ; Bialek, Slawomir ; Briedis, Vitalis ; Mair, Alpana ; Rajabian-Soderlund, Rojin ; Arnavielhe, Sylvie ; Bedbrook, Anna ; Czarlewski, Wienczyslawa ; Annesi-Maesano, Isabella ; Anto, Josep M. ; Devillier, Philippe ; De Vries, Govert ; Keil, Thomas ; Sheikh, Aziz ; Orlando, Valentina ; Larenas-Linnemann, Désirée ; Cecchi, Lorenzo ; De Feo, Giulia ; Illario, M. ; Stellato, Cristiana ; Fonseca, Joao ; Malva, Joao ; Morais-Almeida, Mario ; Pereira, Ana Maria ; Todo-Bom, Ana Maria ; Kvedariene, Violeta ; Valiulis, Arunas ; Bergmann, Karl Christian ; Klimek, Ludger ; Mösges, Ralph ; Pfaar, Oliver ; Zuberbier, Torsten ; Cardona, Vicky ; Mullol, Joaquim ; Papadopoulos, Nikos G. ; Prokopakis, Emmanuel P. ; Bewick, Mike ; Ryan, Dermot ; Roller-Wirnsberger, Regina E. ; Tomazic, Peter Valentin ; Cruz, Alvaro A. ; Kuna, Piotr ; Samolinski, Boleslaw ; Fokkens, Wytske J. ; Reitsma, Sietze ; Bosse, Isabelle ; Fontaine, Jean François ; Laune, Daniel ; Haahtela, Tari ; Toppila-Salmi, Sanna ; Bachert, Claus ; Hellings, Peter W. ; Melén, Erik ; Wickman, Magnus ; Bindslev-Jensen, Carsten ; Eller, Esben ; O'Hehir, Robyn E. ; Cingi, Cemal ; Gemicioğlu, Bilun ; Kalayci, Omer ; Ivancevich, Juan Carlos ; Bousquet, Jean ; the MASK group. / Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study. In: Clinical and Experimental Allergy. 2019 ; Vol. 49, No. 4. pp. 442-460.
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title = "Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study",
abstract = "Background: Mobile technology may help to better understand the adherence to treatment. MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries. Objectives: To assess the adherence to treatment in allergic rhinitis patients using the Allergy Diary App. Methods: An observational cross-sectional study was carried out on all users who filled in the Allergy Diary from 1 January 2016 to 1 August 2017. Secondary adherence was assessed by using the modified Medication Possession Ratio (MPR) and the Proportion of days covered (PDC) approach. Results: A total of 12 143 users were registered. A total of 6 949 users reported at least one VAS data recording. Among them, 1 887 users reported ≥7 VAS data. About 1 195 subjects were included in the analysis of adherence. One hundred and thirty-six (11.28{\%}) users were adherent (MPR ≥70{\%} and PDC ≤1.25), 51 (4.23{\%}) were partly adherent (MPR ≥70{\%} and PDC = 1.50) and 176 (14.60{\%}) were switchers. On the other hand, 832 (69.05{\%}) users were non-adherent to medications (MPR <70{\%}). Of those, the largest group was non-adherent to medications and the time interval was increased in 442 (36.68{\%}) users. Conclusion and clinical relevance: Adherence to treatment is low. The relative efficacy of continuous vs on-demand treatment for allergic rhinitis symptoms is still a matter of debate. This study shows an approach for measuring retrospective adherence based on a mobile app. This also represents a novel approach for analysing medication-taking behaviour in a real-world setting.",
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author = "Enrica Menditto and Elisio Costa and Luis Mid{\~a}o and Sinthia Bosnic-Anticevich and Ettore Novellino and Slawomir Bialek and Vitalis Briedis and Alpana Mair and Rojin Rajabian-Soderlund and Sylvie Arnavielhe and Anna Bedbrook and Wienczyslawa Czarlewski and Isabella Annesi-Maesano and Anto, {Josep M.} and Philippe Devillier and {De Vries}, Govert and Thomas Keil and Aziz Sheikh and Valentina Orlando and D{\'e}sir{\'e}e Larenas-Linnemann and Lorenzo Cecchi and {De Feo}, Giulia and M. Illario and Cristiana Stellato and Joao Fonseca and Joao Malva and Mario Morais-Almeida and Pereira, {Ana Maria} and Todo-Bom, {Ana Maria} and Violeta Kvedariene and Arunas Valiulis and Bergmann, {Karl Christian} and Ludger Klimek and Ralph M{\"o}sges and Oliver Pfaar and Torsten Zuberbier and Vicky Cardona and Joaquim Mullol and Papadopoulos, {Nikos G.} and Prokopakis, {Emmanuel P.} and Mike Bewick and Dermot Ryan and Roller-Wirnsberger, {Regina E.} and Tomazic, {Peter Valentin} and Cruz, {Alvaro A.} and Piotr Kuna and Boleslaw Samolinski and Fokkens, {Wytske J.} and Sietze Reitsma and Isabelle Bosse and Fontaine, {Jean Fran{\cc}ois} and Daniel Laune and Tari Haahtela and Sanna Toppila-Salmi and Claus Bachert and Hellings, {Peter W.} and Erik Mel{\'e}n and Magnus Wickman and Carsten Bindslev-Jensen and Esben Eller and O'Hehir, {Robyn E.} and Cemal Cingi and Bilun Gemicioğlu and Omer Kalayci and Ivancevich, {Juan Carlos} and Jean Bousquet and {the MASK group}",
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Menditto, E, Costa, E, Midão, L, Bosnic-Anticevich, S, Novellino, E, Bialek, S, Briedis, V, Mair, A, Rajabian-Soderlund, R, Arnavielhe, S, Bedbrook, A, Czarlewski, W, Annesi-Maesano, I, Anto, JM, Devillier, P, De Vries, G, Keil, T, Sheikh, A, Orlando, V, Larenas-Linnemann, D, Cecchi, L, De Feo, G, Illario, M, Stellato, C, Fonseca, J, Malva, J, Morais-Almeida, M, Pereira, AM, Todo-Bom, AM, Kvedariene, V, Valiulis, A, Bergmann, KC, Klimek, L, Mösges, R, Pfaar, O, Zuberbier, T, Cardona, V, Mullol, J, Papadopoulos, NG, Prokopakis, EP, Bewick, M, Ryan, D, Roller-Wirnsberger, RE, Tomazic, PV, Cruz, AA, Kuna, P, Samolinski, B, Fokkens, WJ, Reitsma, S, Bosse, I, Fontaine, JF, Laune, D, Haahtela, T, Toppila-Salmi, S, Bachert, C, Hellings, PW, Melén, E, Wickman, M, Bindslev-Jensen, C, Eller, E, O'Hehir, RE, Cingi, C, Gemicioğlu, B, Kalayci, O, Ivancevich, JC, Bousquet, J & the MASK group 2019, 'Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study', Clinical and Experimental Allergy, vol. 49, no. 4, pp. 442-460. https://doi.org/10.1111/cea.13333

Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study. / Menditto, Enrica; Costa, Elisio; Midão, Luis; Bosnic-Anticevich, Sinthia; Novellino, Ettore; Bialek, Slawomir; Briedis, Vitalis; Mair, Alpana; Rajabian-Soderlund, Rojin; Arnavielhe, Sylvie; Bedbrook, Anna; Czarlewski, Wienczyslawa; Annesi-Maesano, Isabella; Anto, Josep M.; Devillier, Philippe; De Vries, Govert; Keil, Thomas; Sheikh, Aziz; Orlando, Valentina; Larenas-Linnemann, Désirée; Cecchi, Lorenzo; De Feo, Giulia; Illario, M.; Stellato, Cristiana; Fonseca, Joao; Malva, Joao; Morais-Almeida, Mario; Pereira, Ana Maria; Todo-Bom, Ana Maria; Kvedariene, Violeta; Valiulis, Arunas; Bergmann, Karl Christian; Klimek, Ludger; Mösges, Ralph; Pfaar, Oliver; Zuberbier, Torsten; Cardona, Vicky; Mullol, Joaquim; Papadopoulos, Nikos G.; Prokopakis, Emmanuel P.; Bewick, Mike; Ryan, Dermot; Roller-Wirnsberger, Regina E.; Tomazic, Peter Valentin; Cruz, Alvaro A.; Kuna, Piotr; Samolinski, Boleslaw; Fokkens, Wytske J.; Reitsma, Sietze; Bosse, Isabelle; Fontaine, Jean François; Laune, Daniel; Haahtela, Tari; Toppila-Salmi, Sanna; Bachert, Claus; Hellings, Peter W.; Melén, Erik; Wickman, Magnus; Bindslev-Jensen, Carsten; Eller, Esben; O'Hehir, Robyn E.; Cingi, Cemal; Gemicioğlu, Bilun; Kalayci, Omer; Ivancevich, Juan Carlos; Bousquet, Jean; the MASK group.

In: Clinical and Experimental Allergy, Vol. 49, No. 4, 04.2019, p. 442-460.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study

AU - Menditto, Enrica

AU - Costa, Elisio

AU - Midão, Luis

AU - Bosnic-Anticevich, Sinthia

AU - Novellino, Ettore

AU - Bialek, Slawomir

AU - Briedis, Vitalis

AU - Mair, Alpana

AU - Rajabian-Soderlund, Rojin

AU - Arnavielhe, Sylvie

AU - Bedbrook, Anna

AU - Czarlewski, Wienczyslawa

AU - Annesi-Maesano, Isabella

AU - Anto, Josep M.

AU - Devillier, Philippe

AU - De Vries, Govert

AU - Keil, Thomas

AU - Sheikh, Aziz

AU - Orlando, Valentina

AU - Larenas-Linnemann, Désirée

AU - Cecchi, Lorenzo

AU - De Feo, Giulia

AU - Illario, M.

AU - Stellato, Cristiana

AU - Fonseca, Joao

AU - Malva, Joao

AU - Morais-Almeida, Mario

AU - Pereira, Ana Maria

AU - Todo-Bom, Ana Maria

AU - Kvedariene, Violeta

AU - Valiulis, Arunas

AU - Bergmann, Karl Christian

AU - Klimek, Ludger

AU - Mösges, Ralph

AU - Pfaar, Oliver

AU - Zuberbier, Torsten

AU - Cardona, Vicky

AU - Mullol, Joaquim

AU - Papadopoulos, Nikos G.

AU - Prokopakis, Emmanuel P.

AU - Bewick, Mike

AU - Ryan, Dermot

AU - Roller-Wirnsberger, Regina E.

AU - Tomazic, Peter Valentin

AU - Cruz, Alvaro A.

AU - Kuna, Piotr

AU - Samolinski, Boleslaw

AU - Fokkens, Wytske J.

AU - Reitsma, Sietze

AU - Bosse, Isabelle

AU - Fontaine, Jean François

AU - Laune, Daniel

AU - Haahtela, Tari

AU - Toppila-Salmi, Sanna

AU - Bachert, Claus

AU - Hellings, Peter W.

AU - Melén, Erik

AU - Wickman, Magnus

AU - Bindslev-Jensen, Carsten

AU - Eller, Esben

AU - O'Hehir, Robyn E.

AU - Cingi, Cemal

AU - Gemicioğlu, Bilun

AU - Kalayci, Omer

AU - Ivancevich, Juan Carlos

AU - Bousquet, Jean

AU - the MASK group

PY - 2019/4

Y1 - 2019/4

N2 - Background: Mobile technology may help to better understand the adherence to treatment. MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries. Objectives: To assess the adherence to treatment in allergic rhinitis patients using the Allergy Diary App. Methods: An observational cross-sectional study was carried out on all users who filled in the Allergy Diary from 1 January 2016 to 1 August 2017. Secondary adherence was assessed by using the modified Medication Possession Ratio (MPR) and the Proportion of days covered (PDC) approach. Results: A total of 12 143 users were registered. A total of 6 949 users reported at least one VAS data recording. Among them, 1 887 users reported ≥7 VAS data. About 1 195 subjects were included in the analysis of adherence. One hundred and thirty-six (11.28%) users were adherent (MPR ≥70% and PDC ≤1.25), 51 (4.23%) were partly adherent (MPR ≥70% and PDC = 1.50) and 176 (14.60%) were switchers. On the other hand, 832 (69.05%) users were non-adherent to medications (MPR <70%). Of those, the largest group was non-adherent to medications and the time interval was increased in 442 (36.68%) users. Conclusion and clinical relevance: Adherence to treatment is low. The relative efficacy of continuous vs on-demand treatment for allergic rhinitis symptoms is still a matter of debate. This study shows an approach for measuring retrospective adherence based on a mobile app. This also represents a novel approach for analysing medication-taking behaviour in a real-world setting.

AB - Background: Mobile technology may help to better understand the adherence to treatment. MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries. Objectives: To assess the adherence to treatment in allergic rhinitis patients using the Allergy Diary App. Methods: An observational cross-sectional study was carried out on all users who filled in the Allergy Diary from 1 January 2016 to 1 August 2017. Secondary adherence was assessed by using the modified Medication Possession Ratio (MPR) and the Proportion of days covered (PDC) approach. Results: A total of 12 143 users were registered. A total of 6 949 users reported at least one VAS data recording. Among them, 1 887 users reported ≥7 VAS data. About 1 195 subjects were included in the analysis of adherence. One hundred and thirty-six (11.28%) users were adherent (MPR ≥70% and PDC ≤1.25), 51 (4.23%) were partly adherent (MPR ≥70% and PDC = 1.50) and 176 (14.60%) were switchers. On the other hand, 832 (69.05%) users were non-adherent to medications (MPR <70%). Of those, the largest group was non-adherent to medications and the time interval was increased in 442 (36.68%) users. Conclusion and clinical relevance: Adherence to treatment is low. The relative efficacy of continuous vs on-demand treatment for allergic rhinitis symptoms is still a matter of debate. This study shows an approach for measuring retrospective adherence based on a mobile app. This also represents a novel approach for analysing medication-taking behaviour in a real-world setting.

KW - adherence

KW - mHealth

KW - mobile technology

KW - observational study

KW - rhinitis

KW - treatment

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U2 - 10.1111/cea.13333

DO - 10.1111/cea.13333

M3 - Article

VL - 49

SP - 442

EP - 460

JO - Clinical and Experimental Allergy

JF - Clinical and Experimental Allergy

SN - 0954-7894

IS - 4

ER -

Menditto E, Costa E, Midão L, Bosnic-Anticevich S, Novellino E, Bialek S et al. Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study. Clinical and Experimental Allergy. 2019 Apr;49(4):442-460. https://doi.org/10.1111/cea.13333