ADHD and DAT1: further evidence of paternal over-transmission of risk alleles and haplotype

Ziarih Hawi, Lindsey S W Kent, Matthew James Hill, Richard J Anney, Keely Joanne Brookes, Edwina Barry, Barbara Franke, Tobias Banaschewski, Jan K Buitelaar, Richard P Ebstein, Ana Lucia Miranda, Robert D Oades, Herbert Roeyers, Aribert Rothenberger, Joseph A Sergeant, Edmund J S Sonuga-Barke, Hans Christoph Steinhausen, Stephen V Faraone, Philip J Asherson, Michael Gill

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Abstract

We [Hawi et al. (2005); Am J Hum Genet 77:958-965] reported paternal over-transmission of risk alleles in some ADHD-associated genes. This was particularly clear in the case of the DAT1 30-UTR VNTR. In the current investigation, we analyzed three new sample comprising of 1,248 ADHD nuclear families to examine the allelic over-transmission of DAT1 in ADHD. The IMAGE sample, the largest of the three-replication samples, provides strong support for a parent of origin effect for allele 6 and the 10 repeat allele (intron 8 and 3 -UTR VNTR, respectively) of DAT1. In addition, a similar pattern of overtransmission of paternal risk haplotypes (constructed from the above alleles) was also observed. Some support is also derived from the two smaller samples although neither is independently significant. Although the mechanism driving the paternal over-transmission of the DAT risk alleles is not known, these finding provide further support for this phenomenon
Original languageEnglish
Pages (from-to)97 - 102
Number of pages6
JournalAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume153
Issue number1
DOIs
Publication statusPublished - 2010
Externally publishedYes

Cite this

Hawi, Ziarih ; Kent, Lindsey S W ; Hill, Matthew James ; Anney, Richard J ; Brookes, Keely Joanne ; Barry, Edwina ; Franke, Barbara ; Banaschewski, Tobias ; Buitelaar, Jan K ; Ebstein, Richard P ; Miranda, Ana Lucia ; Oades, Robert D ; Roeyers, Herbert ; Rothenberger, Aribert ; Sergeant, Joseph A ; Sonuga-Barke, Edmund J S ; Steinhausen, Hans Christoph ; Faraone, Stephen V ; Asherson, Philip J ; Gill, Michael. / ADHD and DAT1: further evidence of paternal over-transmission of risk alleles and haplotype. In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2010 ; Vol. 153, No. 1. pp. 97 - 102.
@article{0e5c17000fb74957ae19e648c5d64474,
title = "ADHD and DAT1: further evidence of paternal over-transmission of risk alleles and haplotype",
abstract = "We [Hawi et al. (2005); Am J Hum Genet 77:958-965] reported paternal over-transmission of risk alleles in some ADHD-associated genes. This was particularly clear in the case of the DAT1 30-UTR VNTR. In the current investigation, we analyzed three new sample comprising of 1,248 ADHD nuclear families to examine the allelic over-transmission of DAT1 in ADHD. The IMAGE sample, the largest of the three-replication samples, provides strong support for a parent of origin effect for allele 6 and the 10 repeat allele (intron 8 and 3 -UTR VNTR, respectively) of DAT1. In addition, a similar pattern of overtransmission of paternal risk haplotypes (constructed from the above alleles) was also observed. Some support is also derived from the two smaller samples although neither is independently significant. Although the mechanism driving the paternal over-transmission of the DAT risk alleles is not known, these finding provide further support for this phenomenon",
author = "Ziarih Hawi and Kent, {Lindsey S W} and Hill, {Matthew James} and Anney, {Richard J} and Brookes, {Keely Joanne} and Edwina Barry and Barbara Franke and Tobias Banaschewski and Buitelaar, {Jan K} and Ebstein, {Richard P} and Miranda, {Ana Lucia} and Oades, {Robert D} and Herbert Roeyers and Aribert Rothenberger and Sergeant, {Joseph A} and Sonuga-Barke, {Edmund J S} and Steinhausen, {Hans Christoph} and Faraone, {Stephen V} and Asherson, {Philip J} and Michael Gill",
year = "2010",
doi = "10.1002/ajmg.b.30960",
language = "English",
volume = "153",
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journal = "American Journal of Medical Genetics Part B: Neuropsychiatric Genetics",
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Hawi, Z, Kent, LSW, Hill, MJ, Anney, RJ, Brookes, KJ, Barry, E, Franke, B, Banaschewski, T, Buitelaar, JK, Ebstein, RP, Miranda, AL, Oades, RD, Roeyers, H, Rothenberger, A, Sergeant, JA, Sonuga-Barke, EJS, Steinhausen, HC, Faraone, SV, Asherson, PJ & Gill, M 2010, 'ADHD and DAT1: further evidence of paternal over-transmission of risk alleles and haplotype', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol. 153, no. 1, pp. 97 - 102. https://doi.org/10.1002/ajmg.b.30960

ADHD and DAT1: further evidence of paternal over-transmission of risk alleles and haplotype. / Hawi, Ziarih; Kent, Lindsey S W; Hill, Matthew James; Anney, Richard J; Brookes, Keely Joanne; Barry, Edwina; Franke, Barbara; Banaschewski, Tobias; Buitelaar, Jan K; Ebstein, Richard P; Miranda, Ana Lucia; Oades, Robert D; Roeyers, Herbert; Rothenberger, Aribert; Sergeant, Joseph A; Sonuga-Barke, Edmund J S; Steinhausen, Hans Christoph; Faraone, Stephen V; Asherson, Philip J; Gill, Michael.

In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 153, No. 1, 2010, p. 97 - 102.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - ADHD and DAT1: further evidence of paternal over-transmission of risk alleles and haplotype

AU - Hawi, Ziarih

AU - Kent, Lindsey S W

AU - Hill, Matthew James

AU - Anney, Richard J

AU - Brookes, Keely Joanne

AU - Barry, Edwina

AU - Franke, Barbara

AU - Banaschewski, Tobias

AU - Buitelaar, Jan K

AU - Ebstein, Richard P

AU - Miranda, Ana Lucia

AU - Oades, Robert D

AU - Roeyers, Herbert

AU - Rothenberger, Aribert

AU - Sergeant, Joseph A

AU - Sonuga-Barke, Edmund J S

AU - Steinhausen, Hans Christoph

AU - Faraone, Stephen V

AU - Asherson, Philip J

AU - Gill, Michael

PY - 2010

Y1 - 2010

N2 - We [Hawi et al. (2005); Am J Hum Genet 77:958-965] reported paternal over-transmission of risk alleles in some ADHD-associated genes. This was particularly clear in the case of the DAT1 30-UTR VNTR. In the current investigation, we analyzed three new sample comprising of 1,248 ADHD nuclear families to examine the allelic over-transmission of DAT1 in ADHD. The IMAGE sample, the largest of the three-replication samples, provides strong support for a parent of origin effect for allele 6 and the 10 repeat allele (intron 8 and 3 -UTR VNTR, respectively) of DAT1. In addition, a similar pattern of overtransmission of paternal risk haplotypes (constructed from the above alleles) was also observed. Some support is also derived from the two smaller samples although neither is independently significant. Although the mechanism driving the paternal over-transmission of the DAT risk alleles is not known, these finding provide further support for this phenomenon

AB - We [Hawi et al. (2005); Am J Hum Genet 77:958-965] reported paternal over-transmission of risk alleles in some ADHD-associated genes. This was particularly clear in the case of the DAT1 30-UTR VNTR. In the current investigation, we analyzed three new sample comprising of 1,248 ADHD nuclear families to examine the allelic over-transmission of DAT1 in ADHD. The IMAGE sample, the largest of the three-replication samples, provides strong support for a parent of origin effect for allele 6 and the 10 repeat allele (intron 8 and 3 -UTR VNTR, respectively) of DAT1. In addition, a similar pattern of overtransmission of paternal risk haplotypes (constructed from the above alleles) was also observed. Some support is also derived from the two smaller samples although neither is independently significant. Although the mechanism driving the paternal over-transmission of the DAT risk alleles is not known, these finding provide further support for this phenomenon

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U2 - 10.1002/ajmg.b.30960

DO - 10.1002/ajmg.b.30960

M3 - Article

VL - 153

SP - 97

EP - 102

JO - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

SN - 1552-4841

IS - 1

ER -