ADHD and DAT1: further evidence of paternal over-transmission of risk alleles and haplotype

Ziarih Hawi, Lindsey S W Kent, Matthew James Hill, Richard J Anney, Keely Joanne Brookes, Edwina Barry, Barbara Franke, Tobias Banaschewski, Jan K Buitelaar, Richard P Ebstein, Ana Lucia Miranda, Robert D Oades, Herbert Roeyers, Aribert Rothenberger, Joseph A Sergeant, Edmund J S Sonuga-Barke, Hans Christoph Steinhausen, Stephen V Faraone, Philip J Asherson, Michael Gill

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28 Citations (Scopus)

Abstract

We [Hawi et al. (2005); Am J Hum Genet 77:958-965] reported paternal over-transmission of risk alleles in some ADHD-associated genes. This was particularly clear in the case of the DAT1 30-UTR VNTR. In the current investigation, we analyzed three new sample comprising of 1,248 ADHD nuclear families to examine the allelic over-transmission of DAT1 in ADHD. The IMAGE sample, the largest of the three-replication samples, provides strong support for a parent of origin effect for allele 6 and the 10 repeat allele (intron 8 and 3 -UTR VNTR, respectively) of DAT1. In addition, a similar pattern of overtransmission of paternal risk haplotypes (constructed from the above alleles) was also observed. Some support is also derived from the two smaller samples although neither is independently significant. Although the mechanism driving the paternal over-transmission of the DAT risk alleles is not known, these finding provide further support for this phenomenon
Original languageEnglish
Pages (from-to)97 - 102
Number of pages6
JournalAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume153
Issue number1
DOIs
Publication statusPublished - 2010
Externally publishedYes

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