TY - JOUR
T1 - Adequacy of a compartment model for CMRO2 quantitation using 15O-labeled oxygen and PET
T2 - a clearance measurement of 15O-radioactivity following intracarotid bolus injection of 15O-labeled oxyhemoglobin on Macaca fascicularis
AU - Iida, Hidehiro
AU - Iguchi, Satoshi
AU - Teramoto, Noboru
AU - Koshino, Kazuhiro
AU - Zeniya, Tsutomu
AU - Yamamoto, Akihide
AU - Kudomi, Nobuyuki
AU - Moriguchi, Tetsuaki
AU - Hori, Yuki
AU - Enmi, Junichiro
AU - Kawashima, Hidekazu
AU - Shah, Nadim Joni
AU - Nakagawara, Jyoji
PY - 2014/9/1
Y1 - 2014/9/1
N2 - We aimed at evaluating the adequacy of the commonly employed compartmental model for quantitation of cerebral metabolic rate of oxygen (CMRO2) using 15O-labeled oxygen (15O2) and positron emission tomography (PET). Sequential PET imaging was carried out on monkeys following slow bolus injection of blood samples containing 15O 2-oxyhemoglobin (15O2-Hb), 15O- labeled water (H2 15O), and C15O-labeled hemoglobin (C15O-Hb) into the internal carotid artery (ICA). Clearance slopes were assessed in the middle cerebral artery territory of the injected hemisphere. The time-activity curves were bi-exponential for both 15O2-Hb and H2 15O. Single exponential fitting to the early (5 to 40 seconds) and late (80 to 240 seconds) periods after the peak was performed and the 15O2-Hb and H2 15O results were compared. It was found that a significant difference between the clearance rates of the 15O 2-Hb and H2 15O injections is unlikely, which supports the mathematical model that is widely used to describe the kinetics of 15O2-Hb and H2 15O in cerebral tissues and is the basis of recent approaches to simultaneously assess CMRO 2 and cerebral blood flow in a single PET session. However, it should be noted that more data are necessary to unequivocally confirm the result.
AB - We aimed at evaluating the adequacy of the commonly employed compartmental model for quantitation of cerebral metabolic rate of oxygen (CMRO2) using 15O-labeled oxygen (15O2) and positron emission tomography (PET). Sequential PET imaging was carried out on monkeys following slow bolus injection of blood samples containing 15O 2-oxyhemoglobin (15O2-Hb), 15O- labeled water (H2 15O), and C15O-labeled hemoglobin (C15O-Hb) into the internal carotid artery (ICA). Clearance slopes were assessed in the middle cerebral artery territory of the injected hemisphere. The time-activity curves were bi-exponential for both 15O2-Hb and H2 15O. Single exponential fitting to the early (5 to 40 seconds) and late (80 to 240 seconds) periods after the peak was performed and the 15O2-Hb and H2 15O results were compared. It was found that a significant difference between the clearance rates of the 15O 2-Hb and H2 15O injections is unlikely, which supports the mathematical model that is widely used to describe the kinetics of 15O2-Hb and H2 15O in cerebral tissues and is the basis of recent approaches to simultaneously assess CMRO 2 and cerebral blood flow in a single PET session. However, it should be noted that more data are necessary to unequivocally confirm the result.
UR - http://www.scopus.com/inward/record.url?scp=84908273888&partnerID=8YFLogxK
U2 - 10.1038/jcbfm.2014.118
DO - 10.1038/jcbfm.2014.118
M3 - Article
C2 - 25005879
AN - SCOPUS:84908273888
SN - 0271-678X
VL - 34
SP - 1434
EP - 1439
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
IS - 9
ER -