Adenovirus tubulointerstitial nephritis presenting as a renal allograft space occupying lesion

Andy Kim Ho Lim, Sarah Parsons, Francesco Ierino

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Abstract

This report describes a case of adenovirus infection in a renal allograft 36 days after transplantation that presented with transient macroscopic hematuria, prominent systemic features and acute renal dysfunction. The patient had persistent high fevers despite broad antibiotic cover. A CT scan demonstrated a new discrete space occupying lesion in the allograft, which was devoid of blood flow on Doppler sonography. A targeted renal biopsy showed florid and focal necrotizing interstitial nephritis with intranuclear tubular viral inclusions. Treatment with ganciclovir and reduction in immunosuppression resulted in a rapid improvement, lmmunohistochemistry and electron microscopy confirmed adenovirus infection. This case demonstrates an uncommon presentation of necrotizing adenoviral nephropathy, which should be considered in cases of renal allograft mass lesions.

Original languageEnglish
Pages (from-to)2062-2066
Number of pages5
JournalAmerican Journal of Transplantation
Volume5
Issue number8
DOIs
Publication statusPublished - 1 Aug 2005
Externally publishedYes

Keywords

  • Adenovirus
  • Kidney space occupying lesion
  • Kidney transplantation
  • Necrotizing interstitial nephritis

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