Adenosine-activated nanochannels inspired by G-protein-coupled receptors

Pei Li, Xiang-Yu Kong, Ganhua Xie, Kai Xiao, Zhen Zhang, Liping Wen, Lei Jiang

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

A bioinspired adenosine activated nanodevice is demonstrated in which the conformations of the designed aptamer change and cause signal transmission according to the emergence of adenosine. This bioinspired system exhibits very high response ratios (activated/nonactivated ratio up to 614) and excellent stability and reversibility, and shows promising applications in the fields of biosensors, pharmaceutica, and healthcare systems.

Original languageEnglish
Pages (from-to)1854-1858
Number of pages5
JournalSmall
Volume12
Issue number14
DOIs
Publication statusPublished - 13 Apr 2016
Externally publishedYes

Keywords

  • adenosine
  • Aptamers
  • Bioinspired
  • Nanochannels
  • Nanodevices

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