Adenosine-activated nanochannels inspired by G-protein-coupled receptors

Pei Li; Xiang-Yu Kong; Ganhua Xie; Kai Xiao; Zhen Zhang; Liping Wen; Lei Jiang

doi:10.1002/smll.201503863

Adenosine-activated nanochannels inspired by G-protein-coupled receptors

Pei Li, Xiang-Yu Kong, Ganhua Xie, Kai Xiao, Zhen Zhang, Liping Wen, Lei Jiang

Research output: Contribution to journal › Article › Research › peer-review

29 Citations (Scopus)

Abstract

A bioinspired adenosine activated nanodevice is demonstrated in which the conformations of the designed aptamer change and cause signal transmission according to the emergence of adenosine. This bioinspired system exhibits very high response ratios (activated/nonactivated ratio up to 614) and excellent stability and reversibility, and shows promising applications in the fields of biosensors, pharmaceutica, and healthcare systems.

Original language	English
Pages (from-to)	1854-1858
Number of pages	5
Journal	Small
Volume	12
Issue number	14
DOIs	https://doi.org/10.1002/smll.201503863
Publication status	Published - 13 Apr 2016
Externally published	Yes

Keywords

adenosine
Aptamers
Bioinspired
Nanochannels
Nanodevices

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10.1002/smll.201503863

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AU - Wen, Liping

AU - Jiang, Lei

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Adenosine-activated nanochannels inspired by G-protein-coupled receptors

Abstract

Keywords

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