Addressing unmet needs in understanding asthma mechanisms

Michael R. Edwards, Sejal Saglani, Jurgen Schwarze, Chrysanthi Skevaki, Jaclyn Ann Smith, Ben Ainsworth, Mark Almond, Evangelos Andreakos, Maria G. Belvisi, Kian Fan Chung, William Cookson, Paul Cullinan, Catherine Hawrylowicz, Marek Lommatzsch, David Jackson, Rene Lutter, Benjamin Marsland, Miriam Moffatt, Meera M. Thomas, J. Christian Virchow & 5 others Georgina Xanthou, Jessica Edwards, Samantha Walker, Sebastian L. Johnston, on behalf of the members of the EARIP WP2 working group

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Asthma is a heterogeneous, complex disease with clinical phenotypes that incorporate persistent symptoms and acute exacerbations. It affects many millions of Europeans throughout their education and working lives and puts a heavy cost on European productivity. There is a wide spectrum of disease severity and control. Therapeutic advances have been slow despite greater understanding of basic mechanisms and the lack of satisfactory preventative and disease modifying management for asthma constitutes a significant unmet clinical need. Preventing, treating and ultimately curing asthma requires co-ordinated research and innovation across Europe. The European Asthma Research and Innovation Partnership (EARIP) is an FP7-funded programme which has taken a co-ordinated and integrated approach to analysing the future of asthma research and development. This report aims to identify the mechanistic areas in which investment is required to bring about significant improvements in asthma outcomes.

Original languageEnglish
Article number1602448
Number of pages43
JournalEuropean Respiratory Journal
Volume49
Issue number5
DOIs
Publication statusPublished - 1 May 2017
Externally publishedYes

Cite this

Edwards, M. R., Saglani, S., Schwarze, J., Skevaki, C., Smith, J. A., Ainsworth, B., ... on behalf of the members of the EARIP WP2 working group (2017). Addressing unmet needs in understanding asthma mechanisms. European Respiratory Journal, 49(5), [1602448]. https://doi.org/10.1183/13993003.02448-2016
Edwards, Michael R. ; Saglani, Sejal ; Schwarze, Jurgen ; Skevaki, Chrysanthi ; Smith, Jaclyn Ann ; Ainsworth, Ben ; Almond, Mark ; Andreakos, Evangelos ; Belvisi, Maria G. ; Chung, Kian Fan ; Cookson, William ; Cullinan, Paul ; Hawrylowicz, Catherine ; Lommatzsch, Marek ; Jackson, David ; Lutter, Rene ; Marsland, Benjamin ; Moffatt, Miriam ; Thomas, Meera M. ; Virchow, J. Christian ; Xanthou, Georgina ; Edwards, Jessica ; Walker, Samantha ; Johnston, Sebastian L. ; on behalf of the members of the EARIP WP2 working group. / Addressing unmet needs in understanding asthma mechanisms. In: European Respiratory Journal. 2017 ; Vol. 49, No. 5.
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Edwards, MR, Saglani, S, Schwarze, J, Skevaki, C, Smith, JA, Ainsworth, B, Almond, M, Andreakos, E, Belvisi, MG, Chung, KF, Cookson, W, Cullinan, P, Hawrylowicz, C, Lommatzsch, M, Jackson, D, Lutter, R, Marsland, B, Moffatt, M, Thomas, MM, Virchow, JC, Xanthou, G, Edwards, J, Walker, S, Johnston, SL & on behalf of the members of the EARIP WP2 working group 2017, 'Addressing unmet needs in understanding asthma mechanisms', European Respiratory Journal, vol. 49, no. 5, 1602448. https://doi.org/10.1183/13993003.02448-2016

Addressing unmet needs in understanding asthma mechanisms. / Edwards, Michael R.; Saglani, Sejal; Schwarze, Jurgen; Skevaki, Chrysanthi; Smith, Jaclyn Ann; Ainsworth, Ben; Almond, Mark; Andreakos, Evangelos; Belvisi, Maria G.; Chung, Kian Fan; Cookson, William; Cullinan, Paul; Hawrylowicz, Catherine; Lommatzsch, Marek; Jackson, David; Lutter, Rene; Marsland, Benjamin; Moffatt, Miriam; Thomas, Meera M.; Virchow, J. Christian; Xanthou, Georgina; Edwards, Jessica; Walker, Samantha; Johnston, Sebastian L.; on behalf of the members of the EARIP WP2 working group.

In: European Respiratory Journal, Vol. 49, No. 5, 1602448, 01.05.2017.

Research output: Contribution to journalReview ArticleResearchpeer-review

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T1 - Addressing unmet needs in understanding asthma mechanisms

AU - Edwards, Michael R.

AU - Saglani, Sejal

AU - Schwarze, Jurgen

AU - Skevaki, Chrysanthi

AU - Smith, Jaclyn Ann

AU - Ainsworth, Ben

AU - Almond, Mark

AU - Andreakos, Evangelos

AU - Belvisi, Maria G.

AU - Chung, Kian Fan

AU - Cookson, William

AU - Cullinan, Paul

AU - Hawrylowicz, Catherine

AU - Lommatzsch, Marek

AU - Jackson, David

AU - Lutter, Rene

AU - Marsland, Benjamin

AU - Moffatt, Miriam

AU - Thomas, Meera M.

AU - Virchow, J. Christian

AU - Xanthou, Georgina

AU - Edwards, Jessica

AU - Walker, Samantha

AU - Johnston, Sebastian L.

AU - on behalf of the members of the EARIP WP2 working group

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Asthma is a heterogeneous, complex disease with clinical phenotypes that incorporate persistent symptoms and acute exacerbations. It affects many millions of Europeans throughout their education and working lives and puts a heavy cost on European productivity. There is a wide spectrum of disease severity and control. Therapeutic advances have been slow despite greater understanding of basic mechanisms and the lack of satisfactory preventative and disease modifying management for asthma constitutes a significant unmet clinical need. Preventing, treating and ultimately curing asthma requires co-ordinated research and innovation across Europe. The European Asthma Research and Innovation Partnership (EARIP) is an FP7-funded programme which has taken a co-ordinated and integrated approach to analysing the future of asthma research and development. This report aims to identify the mechanistic areas in which investment is required to bring about significant improvements in asthma outcomes.

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DO - 10.1183/13993003.02448-2016

M3 - Review Article

VL - 49

JO - European Respiratory Journal

JF - European Respiratory Journal

SN - 0903-1936

IS - 5

M1 - 1602448

ER -

Edwards MR, Saglani S, Schwarze J, Skevaki C, Smith JA, Ainsworth B et al. Addressing unmet needs in understanding asthma mechanisms. European Respiratory Journal. 2017 May 1;49(5). 1602448. https://doi.org/10.1183/13993003.02448-2016