Addressing challenges of high spatial resolution UHF fMRI for group analysis of higher-order cognitive tasks: An inter-sensory task directing attention between visual and somatosensory domains

Kevin M. Aquino, Rodika Sokoliuk, Daisie O. Pakenham, Rosa Maria Sanchez-Panchuelo, Simon Hanslmayr, Stephen D. Mayhew, Karen J. Mullinger, Susan T. Francis

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Functional MRI at ultra-high field (UHF, ≥7 T) provides significant increases in BOLD contrast-to-noise ratio (CNR) compared with conventional field strength (3 T), and has been exploited for reduced field-of-view, high spatial resolution mapping of primary sensory areas. Applying these high spatial resolution methods to investigate whole brain functional responses to higher-order cognitive tasks leads to a number of challenges, in particular how to perform robust group-level statistical analyses. This study addresses these challenges using an inter-sensory cognitive task which modulates top-down attention at graded levels between the visual and somatosensory domains. At the individual level, highly focal functional activation to the task and task difficulty (modulated by attention levels) were detectable due to the high CNR at UHF. However, to assess group level effects, both anatomical and functional variability must be considered during analysis. We demonstrate the importance of surface over volume normalisation and the requirement of no spatial smoothing when assessing highly focal activity. Using novel group analysis on anatomically parcellated brain regions, we show that in higher cognitive areas (parietal and dorsal-lateral-prefrontal cortex) fMRI responses to graded attention levels were modulated quadratically, whilst in visual cortex and VIP, responses were modulated linearly. These group fMRI responses were not seen clearly using conventional second-level GLM analyses, illustrating the limitations of a conventional approach when investigating such focal responses in higher cognitive regions which are more anatomically variable. The approaches demonstrated here complement other advanced analysis methods such as multivariate pattern analysis, allowing UHF to be fully exploited in cognitive neuroscience.

Original languageEnglish
Pages (from-to)1298-1316
Number of pages19
JournalHuman Brain Mapping
Volume40
Issue number4
DOIs
Publication statusPublished - 1 Mar 2019

Keywords

  • 7 T
  • attention modulation
  • directed attention
  • fMRI
  • MRI
  • multi-sensory domain
  • somatosensory
  • ultra-high field
  • visual

Cite this

Aquino, Kevin M. ; Sokoliuk, Rodika ; Pakenham, Daisie O. ; Sanchez-Panchuelo, Rosa Maria ; Hanslmayr, Simon ; Mayhew, Stephen D. ; Mullinger, Karen J. ; Francis, Susan T. / Addressing challenges of high spatial resolution UHF fMRI for group analysis of higher-order cognitive tasks : An inter-sensory task directing attention between visual and somatosensory domains. In: Human Brain Mapping. 2019 ; Vol. 40, No. 4. pp. 1298-1316.
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abstract = "Functional MRI at ultra-high field (UHF, ≥7 T) provides significant increases in BOLD contrast-to-noise ratio (CNR) compared with conventional field strength (3 T), and has been exploited for reduced field-of-view, high spatial resolution mapping of primary sensory areas. Applying these high spatial resolution methods to investigate whole brain functional responses to higher-order cognitive tasks leads to a number of challenges, in particular how to perform robust group-level statistical analyses. This study addresses these challenges using an inter-sensory cognitive task which modulates top-down attention at graded levels between the visual and somatosensory domains. At the individual level, highly focal functional activation to the task and task difficulty (modulated by attention levels) were detectable due to the high CNR at UHF. However, to assess group level effects, both anatomical and functional variability must be considered during analysis. We demonstrate the importance of surface over volume normalisation and the requirement of no spatial smoothing when assessing highly focal activity. Using novel group analysis on anatomically parcellated brain regions, we show that in higher cognitive areas (parietal and dorsal-lateral-prefrontal cortex) fMRI responses to graded attention levels were modulated quadratically, whilst in visual cortex and VIP, responses were modulated linearly. These group fMRI responses were not seen clearly using conventional second-level GLM analyses, illustrating the limitations of a conventional approach when investigating such focal responses in higher cognitive regions which are more anatomically variable. The approaches demonstrated here complement other advanced analysis methods such as multivariate pattern analysis, allowing UHF to be fully exploited in cognitive neuroscience.",
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Addressing challenges of high spatial resolution UHF fMRI for group analysis of higher-order cognitive tasks : An inter-sensory task directing attention between visual and somatosensory domains. / Aquino, Kevin M.; Sokoliuk, Rodika; Pakenham, Daisie O.; Sanchez-Panchuelo, Rosa Maria; Hanslmayr, Simon; Mayhew, Stephen D.; Mullinger, Karen J.; Francis, Susan T.

In: Human Brain Mapping, Vol. 40, No. 4, 01.03.2019, p. 1298-1316.

Research output: Contribution to journalArticleResearchpeer-review

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