Jodie Naim-Feil, Shalini Arunogiri, Primavera A. Spagnolo, Dan I. Lubman

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review


Addiction can be characterized as a persistent state in which there is a diminished ability to regulate the compulsive desire to consume drugs, often regardless of potential adverse consequences. This chapter describes the diagnostic criteria and main clinical features of dependence, including its prevalence, harms and associated comorbidities, as well as the underlying genetics. It outlines the neurobiology of addiction, and discusses the involvement of frontostriatal circuitry in the persistence of drug-seeking behaviours. This will be followed by a review of neuropsychological, neuroimaging and brain stimulation studies of cognitive inhibitory deficits and alterations of the frontostriatal circuitry across specific substance-dependent populations (cocaine, nicotine and alcohol). With regards to the definition of dependence, the World Health Organization (WHO) introduced 'drug dependence' as a description to encompass both physiological dependence and psychological dependence. The chapter discusses that the terms 'dependence' and 'addiction' will be used interchangeably to regulate the compulsive desire to consume drugs, regardless of adverse consequences.
Original languageEnglish
Title of host publicationDevelopmental Disorders of the Brain
EditorsNicole J. Rinehart, John L. Bradshaw, Peter G. Enticott
Place of PublicationOxon UK
PublisherTaylor & Francis
Number of pages23
ISBN (Electronic)9781315692289
ISBN (Print)9781138911888
Publication statusPublished - 2017

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