Acylphenols and dimeric acylphenols from Myristica maxima Warb

Muhamad Aqmal Othman, Yasodha Sivasothy, Chung Yeng Looi, Abdulwali Ablat, Jamaludin Mohamad, Marc Litaudon, Khalijah Awang

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Giganteone E (1), a new dimeric acylphenol was isolated as a minor constituent from the bark of Myristica maxima Warb. The structure of 1 was established on the basis of 1D and 2D NMR techniques and LCMS-IT-TOF analysis. Malabaricones A-C (2-4), giganteones A and C (5 and 6), maingayones A and B (7 and 8), maingayic acid B (9) and β-sitosteryl oleate (10) were also characterized in this plant for the first time. Compound 10 was identified for the first time in the Myristicaceae. Compounds 2 and 5 were active against human prostate cancer cell-lines, thus making this the first report on the prostate cancer inhibiting potential of acylphenols and dimeric acylphenols. Compounds 1, 4, 5, 7 and 8 exhibited potent DPPH free radical scavenging activity. This is the first report on their free radical scavenging capacity.

Original languageEnglish
Pages (from-to)12-17
Number of pages6
JournalFitoterapia
Volume111
DOIs
Publication statusPublished - Jun 2016
Externally publishedYes

Keywords

  • Acylphenols
  • Dimeric acylphenols
  • DPPH free radical scavenging activity
  • Myristica maxima Warb.
  • Myristicaceae
  • Prostate cancer

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