TY - JOUR
T1 - Acylphenols and dimeric acylphenols from Myristica maxima Warb
AU - Othman, Muhamad Aqmal
AU - Sivasothy, Yasodha
AU - Looi, Chung Yeng
AU - Ablat, Abdulwali
AU - Mohamad, Jamaludin
AU - Litaudon, Marc
AU - Awang, Khalijah
N1 - Funding Information:
The authors acknowledge University of Malaya for providing the University Research Grants RP001-2012 and UM.0000091/HIR.C3 which has made this work possible. The authors would also like to thank Professor Mohd Rais Mustafa and Mohadeseh Hasanpourghadi for assisting with the cytotoxic assay.
Publisher Copyright:
© 2016 Published by Elsevier B.V.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/6
Y1 - 2016/6
N2 - Giganteone E (1), a new dimeric acylphenol was isolated as a minor constituent from the bark of Myristica maxima Warb. The structure of 1 was established on the basis of 1D and 2D NMR techniques and LCMS-IT-TOF analysis. Malabaricones A-C (2-4), giganteones A and C (5 and 6), maingayones A and B (7 and 8), maingayic acid B (9) and β-sitosteryl oleate (10) were also characterized in this plant for the first time. Compound 10 was identified for the first time in the Myristicaceae. Compounds 2 and 5 were active against human prostate cancer cell-lines, thus making this the first report on the prostate cancer inhibiting potential of acylphenols and dimeric acylphenols. Compounds 1, 4, 5, 7 and 8 exhibited potent DPPH free radical scavenging activity. This is the first report on their free radical scavenging capacity.
AB - Giganteone E (1), a new dimeric acylphenol was isolated as a minor constituent from the bark of Myristica maxima Warb. The structure of 1 was established on the basis of 1D and 2D NMR techniques and LCMS-IT-TOF analysis. Malabaricones A-C (2-4), giganteones A and C (5 and 6), maingayones A and B (7 and 8), maingayic acid B (9) and β-sitosteryl oleate (10) were also characterized in this plant for the first time. Compound 10 was identified for the first time in the Myristicaceae. Compounds 2 and 5 were active against human prostate cancer cell-lines, thus making this the first report on the prostate cancer inhibiting potential of acylphenols and dimeric acylphenols. Compounds 1, 4, 5, 7 and 8 exhibited potent DPPH free radical scavenging activity. This is the first report on their free radical scavenging capacity.
KW - Acylphenols
KW - Dimeric acylphenols
KW - DPPH free radical scavenging activity
KW - Myristica maxima Warb.
KW - Myristicaceae
KW - Prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=84963720066&partnerID=8YFLogxK
U2 - 10.1016/j.fitote.2016.04.004
DO - 10.1016/j.fitote.2016.04.004
M3 - Article
C2 - 27072985
AN - SCOPUS:84963720066
SN - 0367-326X
VL - 111
SP - 12
EP - 17
JO - Fitoterapia
JF - Fitoterapia
ER -
