Acute monocytic leukemia: A myeloid leukemia subset that may be sensitive to methotrexate

E. Göker; A. Kheradpour; M. Waltham; D. Banerjee; W. P. Tong; Y. Elisseyeff; J. R. Bertino

Acute monocytic leukemia: A myeloid leukemia subset that may be sensitive to methotrexate

E. Göker, A. Kheradpour, M. Waltham, D. Banerjee, W. P. Tong, Y. Elisseyeff, J. R. Bertino

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Impaired polyglutamylation of methotrexate (MTX) and thus poor retention is believed to be the basis of intrinsic resistance in blasts from patients with acute myeloid leukemia (AML) to MTX. We studied additional samples from patients with this disease, and confirmed that polyglutamylation of MTX was poor in ANLL blast cells. However, in one subset of ANLL, acute monocytic leukemia, (M5) leukemia blasts were found to be capable of accumulating and forming long-chain MTX polyglutamates. An acute monocytic leukemia cell line, THP-1 also was found to accumulate high levels of MTX polyglutamates and was relatively sensitive to MTX, strengthening the concept that M5 blasts may be sensitive to this drug. MTX may be an overlooked drug for the treatment of acute monocytic leukemia.

Original language	English
Pages (from-to)	274-276
Number of pages	3
Journal	Leukemia
Volume	9
Issue number	2
Publication status	Published - 1 Jan 1995
Externally published	Yes

Keywords

Acute monocytic leukemia
Methotrexate
Polyglutamylation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "Impaired polyglutamylation of methotrexate (MTX) and thus poor retention is believed to be the basis of intrinsic resistance in blasts from patients with acute myeloid leukemia (AML) to MTX. We studied additional samples from patients with this disease, and confirmed that polyglutamylation of MTX was poor in ANLL blast cells. However, in one subset of ANLL, acute monocytic leukemia, (M5) leukemia blasts were found to be capable of accumulating and forming long-chain MTX polyglutamates. An acute monocytic leukemia cell line, THP-1 also was found to accumulate high levels of MTX polyglutamates and was relatively sensitive to MTX, strengthening the concept that M5 blasts may be sensitive to this drug. MTX may be an overlooked drug for the treatment of acute monocytic leukemia.",

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T1 - Acute monocytic leukemia

T2 - A myeloid leukemia subset that may be sensitive to methotrexate

AU - Göker, E.

AU - Kheradpour, A.

AU - Waltham, M.

AU - Banerjee, D.

AU - Tong, W. P.

AU - Elisseyeff, Y.

AU - Bertino, J. R.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Impaired polyglutamylation of methotrexate (MTX) and thus poor retention is believed to be the basis of intrinsic resistance in blasts from patients with acute myeloid leukemia (AML) to MTX. We studied additional samples from patients with this disease, and confirmed that polyglutamylation of MTX was poor in ANLL blast cells. However, in one subset of ANLL, acute monocytic leukemia, (M5) leukemia blasts were found to be capable of accumulating and forming long-chain MTX polyglutamates. An acute monocytic leukemia cell line, THP-1 also was found to accumulate high levels of MTX polyglutamates and was relatively sensitive to MTX, strengthening the concept that M5 blasts may be sensitive to this drug. MTX may be an overlooked drug for the treatment of acute monocytic leukemia.

AB - Impaired polyglutamylation of methotrexate (MTX) and thus poor retention is believed to be the basis of intrinsic resistance in blasts from patients with acute myeloid leukemia (AML) to MTX. We studied additional samples from patients with this disease, and confirmed that polyglutamylation of MTX was poor in ANLL blast cells. However, in one subset of ANLL, acute monocytic leukemia, (M5) leukemia blasts were found to be capable of accumulating and forming long-chain MTX polyglutamates. An acute monocytic leukemia cell line, THP-1 also was found to accumulate high levels of MTX polyglutamates and was relatively sensitive to MTX, strengthening the concept that M5 blasts may be sensitive to this drug. MTX may be an overlooked drug for the treatment of acute monocytic leukemia.

KW - Acute monocytic leukemia

KW - Methotrexate

KW - Polyglutamylation

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M3 - Article

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Acute monocytic leukemia: A myeloid leukemia subset that may be sensitive to methotrexate

Abstract

Keywords

UN SDGs

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