Acute kidney injury secondary to severe delayed haemolysis in intravenous artesunate use for severe malaria

Kai Wen Leong; Kasha P. Singh; Karin Leder; Steven Y.C. Tong

doi:10.1136/bcr-2020-237501

Acute kidney injury secondary to severe delayed haemolysis in intravenous artesunate use for severe malaria

Kai Wen Leong, Kasha P. Singh, Karin Leder, Steven Y.C. Tong

Research output: Contribution to journal › Article › Other › peer-review

3 Citations (Scopus)

Abstract

The use of artemisinin derivatives has been recommended by the WHO guidelines in malaria treatment largely due to its rapid parasite clearance and safety profile. This case report details the development of delayed haemolysis and subsequent severe acute kidney injury (AKI) 13 days after commencing intravenous artesunate treatment for malaria in an Australian returned traveller. Delayed haemolysis may be an under-recognised complication following artesunate use and if severe, can be complicated by AKI. Therefore, close patient follow-up following treatment is required to ensure prompt recognition of this phenomenon.

Original language	English
Article number	e237501
Number of pages	3
Journal	BMJ Case Reports
Volume	14
Issue number	1
DOIs	https://doi.org/10.1136/bcr-2020-237501
Publication status	Published - Jan 2021

Keywords

acute renal failure
drugs: infectious diseases
haematology (incl blood transfusion)
tropical medicine (infectious disease)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/bcr-2020-237501

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title = "Acute kidney injury secondary to severe delayed haemolysis in intravenous artesunate use for severe malaria",

abstract = "The use of artemisinin derivatives has been recommended by the WHO guidelines in malaria treatment largely due to its rapid parasite clearance and safety profile. This case report details the development of delayed haemolysis and subsequent severe acute kidney injury (AKI) 13 days after commencing intravenous artesunate treatment for malaria in an Australian returned traveller. Delayed haemolysis may be an under-recognised complication following artesunate use and if severe, can be complicated by AKI. Therefore, close patient follow-up following treatment is required to ensure prompt recognition of this phenomenon.",

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author = "Leong, {Kai Wen} and Singh, {Kasha P.} and Karin Leder and Tong, {Steven Y.C.}",

year = "2021",

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AU - Leong, Kai Wen

AU - Singh, Kasha P.

AU - Leder, Karin

AU - Tong, Steven Y.C.

PY - 2021/1

Y1 - 2021/1

N2 - The use of artemisinin derivatives has been recommended by the WHO guidelines in malaria treatment largely due to its rapid parasite clearance and safety profile. This case report details the development of delayed haemolysis and subsequent severe acute kidney injury (AKI) 13 days after commencing intravenous artesunate treatment for malaria in an Australian returned traveller. Delayed haemolysis may be an under-recognised complication following artesunate use and if severe, can be complicated by AKI. Therefore, close patient follow-up following treatment is required to ensure prompt recognition of this phenomenon.

AB - The use of artemisinin derivatives has been recommended by the WHO guidelines in malaria treatment largely due to its rapid parasite clearance and safety profile. This case report details the development of delayed haemolysis and subsequent severe acute kidney injury (AKI) 13 days after commencing intravenous artesunate treatment for malaria in an Australian returned traveller. Delayed haemolysis may be an under-recognised complication following artesunate use and if severe, can be complicated by AKI. Therefore, close patient follow-up following treatment is required to ensure prompt recognition of this phenomenon.

KW - acute renal failure

KW - drugs: infectious diseases

KW - haematology (incl blood transfusion)

KW - tropical medicine (infectious disease)

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AN - SCOPUS:85100252186

SN - 1757-790X

VL - 14

JO - BMJ Case Reports

JF - BMJ Case Reports

IS - 1

M1 - e237501

ER -

Acute kidney injury secondary to severe delayed haemolysis in intravenous artesunate use for severe malaria

Abstract

Keywords

UN SDGs

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