Research output per year
Research output per year
Carole Ichai, Christophe Vinsonneau, Bertrand Souweine, Fabien Armando, Emmanuel Canet, Christophe Clec’h, Jean Michel Constantin, Michaël Darmon, Jacques Duranteau, Théophille Gaillot, Arnaud Garnier, Laurent Jacob, Olivier Joannes-Boyau, Laurent Juillard, Didier Journois, Alexandre Lautrette, Laurent Muller, Matthieu Legrand, Nicolas Lerolle, Thomas Rimmelé
Research output: Contribution to journal › Review Article › Other › peer-review
Acute kidney injury (AKI) is a syndrome that has progressed a great deal over the last 20 years. The decrease in urine output and the increase in classical renal biomarkers, such as blood urea nitrogen and serum creatinine, have largely been used as surrogate markers for decreased glomerular filtration rate (GFR), which defines AKI. However, using such markers of GFR as criteria for diagnosing AKI has several limits including the difficult diagnosis of non-organic AKI, also called “functional renal insufficiency” or “pre-renal insufficiency”. This situation is characterized by an oliguria and an increase in creatininemia as a consequence of a reduction in renal blood flow related to systemic haemodynamic abnormalities. In this situation, “renal insufficiency” seems rather inappropriate as kidney function is not impaired. On the contrary, the kidney delivers an appropriate response aiming to recover optimal systemic physiological haemodynamic conditions. Considering the kidney as insufficient is erroneous because this suggests that it does not work correctly, whereas the opposite is occurring, because the kidney is healthy even in a threatening situation. With current definitions of AKI, normalization of volaemia is needed before defining AKI in order to avoid this pitfall.
Original language | English |
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Article number | 48 |
Number of pages | 20 |
Journal | Annals of Intensive Care |
Volume | 6 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Dec 2016 |
Externally published | Yes |
Research output: Contribution to journal › Article › Other › peer-review