TY - JOUR
T1 - Acute involution in the tammar wallaby: Identification of genes and putative novel milk proteins implicated in mammary gland function
AU - Khalil, Elie
AU - Digby, Matthew R
AU - Thomson, Peter C
AU - Lefevre, Christophe M
AU - Mailer, Sonia L
AU - Pooley, Cate
AU - Nicholas, Kevin R
PY - 2011
Y1 - 2011
N2 - Marsupials provide a suitable alternative model to studying mammary gland involution. They have evolved a different reproductive strategy to eutherians, giving birth to an altricial young and secreting milk that changes in composition during lactation. In this study, we used a marsupial-specific EST microarray to identify 47 up-regulated genes during mammary gland involution in the tammar wallaby (Macropus eugenii). These include the pro-apoptotic tumor necrosis factor receptor superfamily 21 (TNFRSF21) gene, whose expression in the mammary gland has not previously been reported. Genes encoding putative novel milk proteins which may protect the mammary gland from infection were also found to be up-regulated, such as amiloride binding protein 1 (ABP1), complement component 1QB (C1QB), complement component 4A (C4A) and colony stimulating factor 2 receptor beta (CSF2Rbeta). Our results show that the marsupial reproductive strategy was successfully exploited to identify genes and putative novel milk proteins implicated in mammary gland involution.
AB - Marsupials provide a suitable alternative model to studying mammary gland involution. They have evolved a different reproductive strategy to eutherians, giving birth to an altricial young and secreting milk that changes in composition during lactation. In this study, we used a marsupial-specific EST microarray to identify 47 up-regulated genes during mammary gland involution in the tammar wallaby (Macropus eugenii). These include the pro-apoptotic tumor necrosis factor receptor superfamily 21 (TNFRSF21) gene, whose expression in the mammary gland has not previously been reported. Genes encoding putative novel milk proteins which may protect the mammary gland from infection were also found to be up-regulated, such as amiloride binding protein 1 (ABP1), complement component 1QB (C1QB), complement component 4A (C4A) and colony stimulating factor 2 receptor beta (CSF2Rbeta). Our results show that the marsupial reproductive strategy was successfully exploited to identify genes and putative novel milk proteins implicated in mammary gland involution.
UR - http://www.ncbi.nlm.nih.gov/pubmed/21419215
U2 - 10.1016/j.ygeno.2011.03.003
DO - 10.1016/j.ygeno.2011.03.003
M3 - Article
SN - 0888-7543
VL - 97
SP - 372
EP - 378
JO - Genomics
JF - Genomics
IS - 6
ER -