Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1353 - 1356 |
| Number of pages | 4 |
| Journal | Science |
| Volume | 338 |
| Issue number | 6112 |
| DOIs | |
| Publication status | Published - 2012 |
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Acute inflammation initiates the regenerative response in the adult zebrafish brain. / Kyritsis, Nikos; Kizil, Caghan; Zocher, Sara; Kroehne, Volker; Kaslin, Jan V; Freudenreich, Dorian; Iltzsche, Anne; Brand, Michael.
In: Science, Vol. 338, No. 6112, 2012, p. 1353 - 1356.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Acute inflammation initiates the regenerative response in the adult zebrafish brain
AU - Kyritsis, Nikos
AU - Kizil, Caghan
AU - Zocher, Sara
AU - Kroehne, Volker
AU - Kaslin, Jan V
AU - Freudenreich, Dorian
AU - Iltzsche, Anne
AU - Brand, Michael
PY - 2012
Y1 - 2012
N2 - The zebrafish regenerates its brain after injury and hence is a useful model organism to study the mechanisms enabling regenerative neurogenesis, which is poorly manifested in mammals. Yet, the signaling mechanisms initiating such a regenerative response in fish are unknown. Using cerebroventricular microinjection of immunogenic particles and immunosuppression assays, we show that inflammation is required and sufficient for enhancing the proliferation of neural progenitors and subsequent neurogenesis by activating injury-induced molecular programs that can be observed after traumatic brain injury. We also identified the cysteinyl leukotriene signaling as an essential component of inflammation on the regenerative process of the adult zebrafish brain. Thus, our results demonstrate that in zebrafish-in contrast to mammals-inflammation is a positive regulator of neuronal regeneration in the central nervous system.
AB - The zebrafish regenerates its brain after injury and hence is a useful model organism to study the mechanisms enabling regenerative neurogenesis, which is poorly manifested in mammals. Yet, the signaling mechanisms initiating such a regenerative response in fish are unknown. Using cerebroventricular microinjection of immunogenic particles and immunosuppression assays, we show that inflammation is required and sufficient for enhancing the proliferation of neural progenitors and subsequent neurogenesis by activating injury-induced molecular programs that can be observed after traumatic brain injury. We also identified the cysteinyl leukotriene signaling as an essential component of inflammation on the regenerative process of the adult zebrafish brain. Thus, our results demonstrate that in zebrafish-in contrast to mammals-inflammation is a positive regulator of neuronal regeneration in the central nervous system.
UR - http://www.sciencemag.org/content/338/6112/1353.full.pdf
U2 - 10.1126/science.1228773
DO - 10.1126/science.1228773
M3 - Article
VL - 338
SP - 1353
EP - 1356
JO - Science
JF - Science
SN - 0036-8075
IS - 6112
ER -