Acute inflammation initiates the regenerative response in the adult zebrafish brain

Nikos Kyritsis, Caghan Kizil, Sara Zocher, Volker Kroehne, Jan V Kaslin, Dorian Freudenreich, Anne Iltzsche, Michael Brand

Research output: Contribution to journalArticleResearchpeer-review

235 Citations (Scopus)

Abstract

The zebrafish regenerates its brain after injury and hence is a useful model organism to study the mechanisms enabling regenerative neurogenesis, which is poorly manifested in mammals. Yet, the signaling mechanisms initiating such a regenerative response in fish are unknown. Using cerebroventricular microinjection of immunogenic particles and immunosuppression assays, we show that inflammation is required and sufficient for enhancing the proliferation of neural progenitors and subsequent neurogenesis by activating injury-induced molecular programs that can be observed after traumatic brain injury. We also identified the cysteinyl leukotriene signaling as an essential component of inflammation on the regenerative process of the adult zebrafish brain. Thus, our results demonstrate that in zebrafish-in contrast to mammals-inflammation is a positive regulator of neuronal regeneration in the central nervous system.
Original languageEnglish
Pages (from-to)1353 - 1356
Number of pages4
JournalScience
Volume338
Issue number6112
DOIs
Publication statusPublished - 2012

Cite this

Kyritsis, N., Kizil, C., Zocher, S., Kroehne, V., Kaslin, J. V., Freudenreich, D., ... Brand, M. (2012). Acute inflammation initiates the regenerative response in the adult zebrafish brain. Science, 338(6112), 1353 - 1356. https://doi.org/10.1126/science.1228773
Kyritsis, Nikos ; Kizil, Caghan ; Zocher, Sara ; Kroehne, Volker ; Kaslin, Jan V ; Freudenreich, Dorian ; Iltzsche, Anne ; Brand, Michael. / Acute inflammation initiates the regenerative response in the adult zebrafish brain. In: Science. 2012 ; Vol. 338, No. 6112. pp. 1353 - 1356.
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Kyritsis, N, Kizil, C, Zocher, S, Kroehne, V, Kaslin, JV, Freudenreich, D, Iltzsche, A & Brand, M 2012, 'Acute inflammation initiates the regenerative response in the adult zebrafish brain', Science, vol. 338, no. 6112, pp. 1353 - 1356. https://doi.org/10.1126/science.1228773

Acute inflammation initiates the regenerative response in the adult zebrafish brain. / Kyritsis, Nikos; Kizil, Caghan; Zocher, Sara; Kroehne, Volker; Kaslin, Jan V; Freudenreich, Dorian; Iltzsche, Anne; Brand, Michael.

In: Science, Vol. 338, No. 6112, 2012, p. 1353 - 1356.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Freudenreich, Dorian

AU - Iltzsche, Anne

AU - Brand, Michael

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AB - The zebrafish regenerates its brain after injury and hence is a useful model organism to study the mechanisms enabling regenerative neurogenesis, which is poorly manifested in mammals. Yet, the signaling mechanisms initiating such a regenerative response in fish are unknown. Using cerebroventricular microinjection of immunogenic particles and immunosuppression assays, we show that inflammation is required and sufficient for enhancing the proliferation of neural progenitors and subsequent neurogenesis by activating injury-induced molecular programs that can be observed after traumatic brain injury. We also identified the cysteinyl leukotriene signaling as an essential component of inflammation on the regenerative process of the adult zebrafish brain. Thus, our results demonstrate that in zebrafish-in contrast to mammals-inflammation is a positive regulator of neuronal regeneration in the central nervous system.

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Kyritsis N, Kizil C, Zocher S, Kroehne V, Kaslin JV, Freudenreich D et al. Acute inflammation initiates the regenerative response in the adult zebrafish brain. Science. 2012;338(6112):1353 - 1356. https://doi.org/10.1126/science.1228773