ACUTE HAEMODYNAMIC RESPONSES TO UNILATERAL RENAL ARTERY STENOSIS IN CONSCIOUS DOGS

Warwick P. Anderson, Robyn L. Woods, Robert L. Kline, Paul I. Korner

Research output: Contribution to journalArticleResearchpeer-review

Abstract

1. The acute responses to renal artery stenosis were studied in chronically instrumented, unanaesthetized dogs. 2. Stenosis of one renal artery produced a rise in arterial pressure and a fall in total peripheral conductance, but no change in cardiac output. 3. The resistance to blood flow of the stenotic kidney 1 h after stenosis was 25% greater than before stenosis. This rise in resistance was due to the resistance of the renal artery stenosis itself. 4. Blood flow to the contralateral kidney fell by 13% (s.e.m. =3) at 1 h and resistance rose by 39% (s.e.m. = 5). 5. Plasma renin activity was elevated approximately 10 fold. 6. Calculations of changes in peripheral conductances following stenosis showed that the stenotic kidney was responsible for 14% of the fall in total peripheral conductance at 1 h, and the contralateral kidney for 18%. 7. Thus acute renal artery stenosis produced a prompt rise in arterial pressure due to reduced peripheral conductance, of which the two kidneys (stenotic and contralateral) were responsible for one‐third.

Original languageEnglish
Pages (from-to)305-309
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Volume12
Issue number3
DOIs
Publication statusPublished - 1985
Externally publishedYes

Keywords

  • cardiac output
  • hypertension
  • renal blood flow
  • renin, total peripheral resistance
  • two‐kidney hypertension.

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