1. The acute responses to renal artery stenosis were studied in chronically instrumented, unanaesthetized dogs. 2. Stenosis of one renal artery produced a rise in arterial pressure and a fall in total peripheral conductance, but no change in cardiac output. 3. The resistance to blood flow of the stenotic kidney 1 h after stenosis was 25% greater than before stenosis. This rise in resistance was due to the resistance of the renal artery stenosis itself. 4. Blood flow to the contralateral kidney fell by 13% (s.e.m. =3) at 1 h and resistance rose by 39% (s.e.m. = 5). 5. Plasma renin activity was elevated approximately 10 fold. 6. Calculations of changes in peripheral conductances following stenosis showed that the stenotic kidney was responsible for 14% of the fall in total peripheral conductance at 1 h, and the contralateral kidney for 18%. 7. Thus acute renal artery stenosis produced a prompt rise in arterial pressure due to reduced peripheral conductance, of which the two kidneys (stenotic and contralateral) were responsible for one‐third.
|Number of pages||5|
|Journal||Clinical and Experimental Pharmacology and Physiology|
|Publication status||Published - 1985|
- cardiac output
- renal blood flow
- renin, total peripheral resistance
- two‐kidney hypertension.