Acute effects of different multivitamin mineral preparations with and without guaraná on mood, cognitive performance and functional brain activation

Andrew Scholey, Isabelle Bauer, Chris Neale, Karen Savage, David Camfield, David White, Silvia Maggini, Andrew Pipingas, Con Stough, Matthew Hughes

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Abstract

Previous work has identified the positive effects of the acute administration of a multivitamin-guaraná preparation during an effortful executive/working memory task. Here, we aimed to differentiate the effects of multivitamins with and without guaraná and to examine the neural substrates of such effects using functional magnetic resonance imaging (fMRI). Following a double-blind, placebo-controlled, randomised, balanced crossover design, 20 participants (mean age 29 ± 5.54 years) consumed multivitamin preparations with or without guaraná (Berocca® Performance and Boost, respectively) and a placebo. Thirty minutes post-treatment, they underwent neurocognitive assessment, consisting of a 10 min Cognitive Demand Battery, with mood ratings taken immediately before and after the battery. Five additional participants underwent post-treatment fMRI scanning during Rapid Visual Information Processing and Inspection Time activation tasks. The multivitamin with guaraná treatment was associated with significantly enhanced Serial Threes performance and self-rated contentment. fMRI revealed that both multivitamin treatments increased activation in areas associated with working memory and attentional processing, with the effect being greater in the multivitamin with guaraná condition. These data confirm the acute benefits of multivitamins with guaraná on mood and cognitive performance. Furthermore, they demonstrate for the first time increased brain activation from multivitamin preparations both with and without guaraná, as measured using fMRI.

Original languageEnglish
Pages (from-to)3589-3604
Number of pages16
JournalNutrients
Volume5
Issue number9
DOIs
Publication statusPublished - 13 Sep 2013
Externally publishedYes

Keywords

  • Attention
  • fMRI
  • Guaraná
  • Mood
  • Multivitamin
  • Neuroimaging
  • Working memory

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