Activity of colistin against heteroresistant Acinetobacter baumannii and emergence of resistance in an in vitro pharmacokinetic/pharmacodynamic model

Chun-Hong Tan, Jian Li, Roger Leigh Nation

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Abstract

Three clinically relevant intermittent regimens, and a continuous infusion, of colistin were simulated in an in vitro pharmacokinetic/pharmacodynamic model against two colistin-heteroresistant strains of Acinetobacter baumannii. Extensive initial killing was followed by regrowth as early as 6 h later; bacterial density in the 24- to 72-h period was within 1 log(10) CFU/ml of growth control. Population analysis profiles revealed extensive emergence of resistant subpopulations regardless of the colistin regimen.
Original languageEnglish
Pages (from-to)3413 - 3415
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number9
Publication statusPublished - 2007

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