Activins in male reproduction

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The activins are growth factors in the transforming growth factor-β (TGFβ) superfamily. They have both endocrine and paracrine roles that are central to male reproductive biology and health. This article gives a general overview of activin structure and signaling activity. Activin action within the pituitary is described in the context of the hypothalamic–pituitary–gonadal axis of the male. Activin intratesticular actions affecting cell fate and organ growth are identified, including distinctions between somatic and germline functions and developmentally regulated effects. Areas where dysregulated activin function may be of relevance to male reproductive pathologies are considered, including infertility, inflammation, and testicular cancer.
Original languageEnglish
Title of host publicationEncyclopedia of Reproduction
Subtitle of host publicationVolume 1: Male Reproduction
EditorsMichael K. Skinner
Place of PublicationOxford UK
PublisherAcademic Press
Number of pages7
ISBN (Electronic)9780128151457
ISBN (Print)9780128118993
Publication statusPublished - 27 Jul 2018

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