Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 188-198 |
| Number of pages | 11 |
| Journal | Molecular and Cellular Endocrinology |
| Volume | 470 |
| DOIs | |
| Publication status | Published - 15 Jul 2017 |
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Activin over-expression in the testis of mice lacking the inhibin α-subunit gene is associated with androgen deficiency and regression of the male reproductive tract. / Wijayarathna, Rukmali; de Kretser, David M.; Meinhardt, Andreas; Middendorff, Ralf; Ludlow, Helen; Groome, Nigel P.; Loveland, Kate A.; Hedger, Mark P.
In: Molecular and Cellular Endocrinology, Vol. 470, 15.07.2017, p. 188-198.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Activin over-expression in the testis of mice lacking the inhibin α-subunit gene is associated with androgen deficiency and regression of the male reproductive tract
AU - Wijayarathna, Rukmali
AU - de Kretser, David M.
AU - Meinhardt, Andreas
AU - Middendorff, Ralf
AU - Ludlow, Helen
AU - Groome, Nigel P.
AU - Loveland, Kate A.
AU - Hedger, Mark P.
PY - 2017/7/15
Y1 - 2017/7/15
N2 - Regionalised interaction of the activins, follistatin and inhibin was investigated in the male reproductive tract of mice lacking the inhibin α-subunit (Inha−/-). Serum and intratesticular activin B, although not activin A and follistatin, were increased in Inha−/- mice at 25 days of age, but all three proteins were elevated at 56 days. None of these proteins were altered within the epididymis and vas deferens at either age. At 25 days, histology of the epididymis and vas deferens was similar to wild-type. At 56 days, the testis contained extensive somatic cell tumours, leading to Leydig cell regression and testosterone deficiency. The epididymis and vas deferens showed epithelial regression and increased prominence of the interstitial stroma. Immunoregulatory and fibrotic gene expression in the epididymis and vas deferens were unchanged. Thus, absence of the inhibin α-subunit has marginal effects on activins in the epididymis and vas deferens, and regression of these tissues is associated with androgen deficiency.
AB - Regionalised interaction of the activins, follistatin and inhibin was investigated in the male reproductive tract of mice lacking the inhibin α-subunit (Inha−/-). Serum and intratesticular activin B, although not activin A and follistatin, were increased in Inha−/- mice at 25 days of age, but all three proteins were elevated at 56 days. None of these proteins were altered within the epididymis and vas deferens at either age. At 25 days, histology of the epididymis and vas deferens was similar to wild-type. At 56 days, the testis contained extensive somatic cell tumours, leading to Leydig cell regression and testosterone deficiency. The epididymis and vas deferens showed epithelial regression and increased prominence of the interstitial stroma. Immunoregulatory and fibrotic gene expression in the epididymis and vas deferens were unchanged. Thus, absence of the inhibin α-subunit has marginal effects on activins in the epididymis and vas deferens, and regression of these tissues is associated with androgen deficiency.
U2 - 10.1016/j.mce.2017.10.013
DO - 10.1016/j.mce.2017.10.013
M3 - Article
VL - 470
SP - 188
EP - 198
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
SN - 0303-7207
ER -