Activin A as a marker of intrauterine infection in women with preterm prelabour rupture of membranes

Ryan Hodges; L Salvador; Donato D'Antona; H Georgiou; Euan Wallace

doi:10.1038/jp.2009.109

Activin A as a marker of intrauterine infection in women with preterm prelabour rupture of membranes

Ryan Hodges, L Salvador, Donato D'Antona, H Georgiou, Euan Wallace

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

OBJECTIVE: To assess maternal serum activin A, an early phase response protein in systemic infection, as an early marker of intrauterine infection in women with preterm prelabour rupture of membranes (PPROM). STUDY DESIGN: A prospective cohort study of women with singleton pregnancies complicated by PPROM at 24 to 34 weeks gestation. Serum was collected for activin A and cytokine measurements. Activin A was measured using commercial enzyme-linked immunosorbent assay. Cytokines were measured using commercial multiplex assay. Pregnancy outcomes including infection were determined by case-record review. RESULT: Eighteen women with PPROM were studied, with seven developing intrauterine infection. Serum activin A in women with and without infection did not differ. Peripheral white cell count, interleukin (IL)-6 and IL-10 were higher (P=0.03, 0.05 and 0.009, respectively) and IL-7 lower (P=0.04) 72 h before delivery in women with infection. CONCLUSION: Activin A is not a clinically useful marker of intrauterine infection in women with PPROM.

Original language	English
Pages (from-to)	22 - 26
Number of pages	5
Journal	Journal of Perinatology
Volume	30
Issue number	1
DOIs	https://doi.org/10.1038/jp.2009.109
Publication status	Published - 2010

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10.1038/jp.2009.109

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title = "Activin A as a marker of intrauterine infection in women with preterm prelabour rupture of membranes",

abstract = "OBJECTIVE: To assess maternal serum activin A, an early phase response protein in systemic infection, as an early marker of intrauterine infection in women with preterm prelabour rupture of membranes (PPROM). STUDY DESIGN: A prospective cohort study of women with singleton pregnancies complicated by PPROM at 24 to 34 weeks gestation. Serum was collected for activin A and cytokine measurements. Activin A was measured using commercial enzyme-linked immunosorbent assay. Cytokines were measured using commercial multiplex assay. Pregnancy outcomes including infection were determined by case-record review. RESULT: Eighteen women with PPROM were studied, with seven developing intrauterine infection. Serum activin A in women with and without infection did not differ. Peripheral white cell count, interleukin (IL)-6 and IL-10 were higher (P=0.03, 0.05 and 0.009, respectively) and IL-7 lower (P=0.04) 72 h before delivery in women with infection. CONCLUSION: Activin A is not a clinically useful marker of intrauterine infection in women with PPROM.",

author = "Ryan Hodges and L Salvador and Donato D'Antona and H Georgiou and Euan Wallace",

year = "2010",

doi = "10.1038/jp.2009.109",

language = "English",

volume = "30",

pages = "22 -- 26",

journal = "Journal of Perinatology",

issn = "0743-8346",

publisher = "Nature Publishing Group",

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T1 - Activin A as a marker of intrauterine infection in women with preterm prelabour rupture of membranes

AU - Hodges, Ryan

AU - Salvador, L

AU - D'Antona, Donato

AU - Georgiou, H

AU - Wallace, Euan

PY - 2010

Y1 - 2010

N2 - OBJECTIVE: To assess maternal serum activin A, an early phase response protein in systemic infection, as an early marker of intrauterine infection in women with preterm prelabour rupture of membranes (PPROM). STUDY DESIGN: A prospective cohort study of women with singleton pregnancies complicated by PPROM at 24 to 34 weeks gestation. Serum was collected for activin A and cytokine measurements. Activin A was measured using commercial enzyme-linked immunosorbent assay. Cytokines were measured using commercial multiplex assay. Pregnancy outcomes including infection were determined by case-record review. RESULT: Eighteen women with PPROM were studied, with seven developing intrauterine infection. Serum activin A in women with and without infection did not differ. Peripheral white cell count, interleukin (IL)-6 and IL-10 were higher (P=0.03, 0.05 and 0.009, respectively) and IL-7 lower (P=0.04) 72 h before delivery in women with infection. CONCLUSION: Activin A is not a clinically useful marker of intrauterine infection in women with PPROM.

AB - OBJECTIVE: To assess maternal serum activin A, an early phase response protein in systemic infection, as an early marker of intrauterine infection in women with preterm prelabour rupture of membranes (PPROM). STUDY DESIGN: A prospective cohort study of women with singleton pregnancies complicated by PPROM at 24 to 34 weeks gestation. Serum was collected for activin A and cytokine measurements. Activin A was measured using commercial enzyme-linked immunosorbent assay. Cytokines were measured using commercial multiplex assay. Pregnancy outcomes including infection were determined by case-record review. RESULT: Eighteen women with PPROM were studied, with seven developing intrauterine infection. Serum activin A in women with and without infection did not differ. Peripheral white cell count, interleukin (IL)-6 and IL-10 were higher (P=0.03, 0.05 and 0.009, respectively) and IL-7 lower (P=0.04) 72 h before delivery in women with infection. CONCLUSION: Activin A is not a clinically useful marker of intrauterine infection in women with PPROM.

UR - http://www.nature.com/jp/journal/v30/n1/pdf/jp2009109a.pdf

U2 - 10.1038/jp.2009.109

DO - 10.1038/jp.2009.109

M3 - Article

SN - 0743-8346

VL - 30

SP - 22

EP - 26

JO - Journal of Perinatology

JF - Journal of Perinatology

IS - 1

ER -

Activin A as a marker of intrauterine infection in women with preterm prelabour rupture of membranes

Abstract

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