Abstract
Activin A is a two-subunit protein belonging to the transforming growth factor β superfamily. First discovered almost three decades ago, it has since been implicated in diverse physiological roles, ranging from wound repair to reproduction. After 30 years of research, altered activin A levels are now understood to be associated with the development of various diseases, making activin A a potential therapeutic target. In pregnancy, the placenta and fetal membranes are major producers of activin A, with significantly enhanced serum concentrations now recognised as a contributor to numerous gestational disorders. Evidence now suggests that circulating levels of activin A may be clinically relevant in the early detection of pregnancy complications, including miscarriage and preeclampsia. This review aims to summarise our current understanding of activin A as a potential diagnostic marker in common pregnancy pathologies.
Original language | English |
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Pages (from-to) | 35-41 |
Number of pages | 7 |
Journal | Placenta |
Volume | 136 |
DOIs | |
Publication status | Published - May 2023 |
Keywords
- Activin A
- Ectopic pregnancy
- Fetal growth restrictio
- Gestational diabetes mellitus
- Miscarriage
- Preeclampsia
- Pregnancy