Active tyrosine phosphatase in immunoprecipitates of multiple isoforms of Ly-5

Melissa C. Southey, L. Jorge Gonez, Mauro S. Sandrin, Bruce E. Kemp

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Using tumour cell lines expressing specific isoforms of murine Ly-5 (molecular weights of 180,000, 200,000 and 240,000) we find that all forms of Ly-5 and immuno-affinity purified forms of Ly-5 contain tyrosyl phosphatase activity. These results demonstrate that these isoforms of Ly-5 belong to the same family of functional receptor-linked tyrosine phosphatases as the human leukocyte common antigen, CD45.

Original languageEnglish
Pages (from-to)299-304
Number of pages6
JournalCellular Signalling
Volume2
Issue number3
DOIs
Publication statusPublished - 1 Jan 1990
Externally publishedYes

Keywords

  • CD45
  • Ly-5
  • receptor
  • tyrosine phosphatase

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