Active tyrosine phosphatase in immunoprecipitates of multiple isoforms of Ly-5

Melissa C. Southey; L. Jorge Gonez; Mauro S. Sandrin; Bruce E. Kemp

doi:10.1016/0898-6568(90)90057-H

Active tyrosine phosphatase in immunoprecipitates of multiple isoforms of Ly-5

Melissa C. Southey, L. Jorge Gonez, Mauro S. Sandrin, Bruce E. Kemp

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Using tumour cell lines expressing specific isoforms of murine Ly-5 (molecular weights of 180,000, 200,000 and 240,000) we find that all forms of Ly-5 and immuno-affinity purified forms of Ly-5 contain tyrosyl phosphatase activity. These results demonstrate that these isoforms of Ly-5 belong to the same family of functional receptor-linked tyrosine phosphatases as the human leukocyte common antigen, CD45.

Original language	English
Pages (from-to)	299-304
Number of pages	6
Journal	Cellular Signalling
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/0898-6568(90)90057-H
Publication status	Published - 1 Jan 1990
Externally published	Yes

Keywords

CD45
Ly-5
receptor
tyrosine phosphatase

Access to Document

10.1016/0898-6568(90)90057-H

Link to publication in Scopus

Cite this

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title = "Active tyrosine phosphatase in immunoprecipitates of multiple isoforms of Ly-5",

abstract = "Using tumour cell lines expressing specific isoforms of murine Ly-5 (molecular weights of 180,000, 200,000 and 240,000) we find that all forms of Ly-5 and immuno-affinity purified forms of Ly-5 contain tyrosyl phosphatase activity. These results demonstrate that these isoforms of Ly-5 belong to the same family of functional receptor-linked tyrosine phosphatases as the human leukocyte common antigen, CD45.",

keywords = "CD45, Ly-5, receptor, tyrosine phosphatase",

author = "Southey, {Melissa C.} and {Jorge Gonez}, L. and Sandrin, {Mauro S.} and Kemp, {Bruce E.}",

year = "1990",

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AU - Southey, Melissa C.

AU - Jorge Gonez, L.

AU - Sandrin, Mauro S.

AU - Kemp, Bruce E.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Using tumour cell lines expressing specific isoforms of murine Ly-5 (molecular weights of 180,000, 200,000 and 240,000) we find that all forms of Ly-5 and immuno-affinity purified forms of Ly-5 contain tyrosyl phosphatase activity. These results demonstrate that these isoforms of Ly-5 belong to the same family of functional receptor-linked tyrosine phosphatases as the human leukocyte common antigen, CD45.

AB - Using tumour cell lines expressing specific isoforms of murine Ly-5 (molecular weights of 180,000, 200,000 and 240,000) we find that all forms of Ly-5 and immuno-affinity purified forms of Ly-5 contain tyrosyl phosphatase activity. These results demonstrate that these isoforms of Ly-5 belong to the same family of functional receptor-linked tyrosine phosphatases as the human leukocyte common antigen, CD45.

KW - CD45

KW - Ly-5

KW - receptor

KW - tyrosine phosphatase

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U2 - 10.1016/0898-6568(90)90057-H

DO - 10.1016/0898-6568(90)90057-H

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