Active surveillance for multidrug-resistant Gram-negative bacteria in the intensive care unit

Iain J Abbott, Adam W Jenney, Denis W Spelman, David V Pilcher, Hanna E Sidjabat, Leisha J Richardson, David L Paterson, Anton Y Peleg

Research output: Contribution to journalArticleResearchpeer-review

Abstract

A short-term program of performing serial active screening cultures (ASC) in the intensive care unit was instituted to establish a method for the detection of antibiotic-resistant Gram-negative bacteria (GNB) and the local rates of colonisation. Of all submitted ASC, 25.9 (30/116 collected swabs) isolated an antibiotic-resistant GNB. ChromID ESBL agar (bioMerieux, France) identified the majority of these organisms, with the additional antibiotic-impregnated media [MacConkey agar (MCA) with ciprofloxacin, MCA with gentamicin and MCA with ceftazidime] adding limited benefit. Compared to swabs performed on admission, 37.8 (14/37) of patients cultured a new antibiotic-resistant isolate on discharge. Serial screening in intensive care has the ability to identify patients with unrecognised colonisation with antibiotic-resistant GNB; however, the increase in the laboratory workload and logistical challenges in the collection of the surveillance swabs may limit this program s expansion.
Original languageEnglish
Pages (from-to)575 - 579
Number of pages5
JournalPathology
Volume47
Issue number6
DOIs
Publication statusPublished - 2015

Cite this

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title = "Active surveillance for multidrug-resistant Gram-negative bacteria in the intensive care unit",
abstract = "A short-term program of performing serial active screening cultures (ASC) in the intensive care unit was instituted to establish a method for the detection of antibiotic-resistant Gram-negative bacteria (GNB) and the local rates of colonisation. Of all submitted ASC, 25.9 (30/116 collected swabs) isolated an antibiotic-resistant GNB. ChromID ESBL agar (bioMerieux, France) identified the majority of these organisms, with the additional antibiotic-impregnated media [MacConkey agar (MCA) with ciprofloxacin, MCA with gentamicin and MCA with ceftazidime] adding limited benefit. Compared to swabs performed on admission, 37.8 (14/37) of patients cultured a new antibiotic-resistant isolate on discharge. Serial screening in intensive care has the ability to identify patients with unrecognised colonisation with antibiotic-resistant GNB; however, the increase in the laboratory workload and logistical challenges in the collection of the surveillance swabs may limit this program s expansion.",
author = "Abbott, {Iain J} and Jenney, {Adam W} and Spelman, {Denis W} and Pilcher, {David V} and Sidjabat, {Hanna E} and Richardson, {Leisha J} and Paterson, {David L} and Peleg, {Anton Y}",
year = "2015",
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language = "English",
volume = "47",
pages = "575 -- 579",
journal = "Pathology",
issn = "0031-3025",
publisher = "Lippincott Williams & Wilkins",
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Active surveillance for multidrug-resistant Gram-negative bacteria in the intensive care unit. / Abbott, Iain J; Jenney, Adam W; Spelman, Denis W; Pilcher, David V; Sidjabat, Hanna E; Richardson, Leisha J; Paterson, David L; Peleg, Anton Y.

In: Pathology, Vol. 47, No. 6, 2015, p. 575 - 579.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Active surveillance for multidrug-resistant Gram-negative bacteria in the intensive care unit

AU - Abbott, Iain J

AU - Jenney, Adam W

AU - Spelman, Denis W

AU - Pilcher, David V

AU - Sidjabat, Hanna E

AU - Richardson, Leisha J

AU - Paterson, David L

AU - Peleg, Anton Y

PY - 2015

Y1 - 2015

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AB - A short-term program of performing serial active screening cultures (ASC) in the intensive care unit was instituted to establish a method for the detection of antibiotic-resistant Gram-negative bacteria (GNB) and the local rates of colonisation. Of all submitted ASC, 25.9 (30/116 collected swabs) isolated an antibiotic-resistant GNB. ChromID ESBL agar (bioMerieux, France) identified the majority of these organisms, with the additional antibiotic-impregnated media [MacConkey agar (MCA) with ciprofloxacin, MCA with gentamicin and MCA with ceftazidime] adding limited benefit. Compared to swabs performed on admission, 37.8 (14/37) of patients cultured a new antibiotic-resistant isolate on discharge. Serial screening in intensive care has the ability to identify patients with unrecognised colonisation with antibiotic-resistant GNB; however, the increase in the laboratory workload and logistical challenges in the collection of the surveillance swabs may limit this program s expansion.

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