Abstract
Metamorphosis is a privileged period for the induction of tolerance to allografts. Transfers of lymphocytes from metamorphosing Xenopus into isogenic adults prevented the rejection of a skin graft differing from the adult host by minor histocompatibility antigens. This implies that active suppression is involved at one step of the induction of tolerance to the self-antigens that differentiate at the time of metamorphosis. The reciprocal experiments of preventing tolerance induction by transfer of normal adult cells into metamorphosing animals failed. However, passive transfer of anti-graft immunity in tolerant animals was partially observed, provided that a transfer of primed cells was done simultaneously with the challenging graft. Thus, memory cells are not as sensitive to the suppression as are the cells that respond in a first set reaction.
| Original language | English |
|---|---|
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | Differentiation |
| Volume | 16 |
| Issue number | 1-3 |
| DOIs | |
| Publication status | Published - 1980 |
| Externally published | Yes |
Cite this
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Active Suppression of the Allogeneic Histocompatibility Reactions During the Metamorphosis of the Clawed Toad Xenopus. / DU PASQUIER, L.; BERNARD, C. C.A.
In: Differentiation, Vol. 16, No. 1-3, 1980, p. 1-7.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Active Suppression of the Allogeneic Histocompatibility Reactions During the Metamorphosis of the Clawed Toad Xenopus
AU - DU PASQUIER, L.
AU - BERNARD, C. C.A.
PY - 1980
Y1 - 1980
N2 - Metamorphosis is a privileged period for the induction of tolerance to allografts. Transfers of lymphocytes from metamorphosing Xenopus into isogenic adults prevented the rejection of a skin graft differing from the adult host by minor histocompatibility antigens. This implies that active suppression is involved at one step of the induction of tolerance to the self-antigens that differentiate at the time of metamorphosis. The reciprocal experiments of preventing tolerance induction by transfer of normal adult cells into metamorphosing animals failed. However, passive transfer of anti-graft immunity in tolerant animals was partially observed, provided that a transfer of primed cells was done simultaneously with the challenging graft. Thus, memory cells are not as sensitive to the suppression as are the cells that respond in a first set reaction.
AB - Metamorphosis is a privileged period for the induction of tolerance to allografts. Transfers of lymphocytes from metamorphosing Xenopus into isogenic adults prevented the rejection of a skin graft differing from the adult host by minor histocompatibility antigens. This implies that active suppression is involved at one step of the induction of tolerance to the self-antigens that differentiate at the time of metamorphosis. The reciprocal experiments of preventing tolerance induction by transfer of normal adult cells into metamorphosing animals failed. However, passive transfer of anti-graft immunity in tolerant animals was partially observed, provided that a transfer of primed cells was done simultaneously with the challenging graft. Thus, memory cells are not as sensitive to the suppression as are the cells that respond in a first set reaction.
UR - http://www.scopus.com/inward/record.url?scp=0018836699&partnerID=8YFLogxK
U2 - 10.1111/j.1432-0436.1980.tb01052.x
DO - 10.1111/j.1432-0436.1980.tb01052.x
M3 - Article
VL - 16
SP - 1
EP - 7
JO - Differentiation
JF - Differentiation
SN - 0301-4681
IS - 1-3
ER -