Active bioparticle manipulation in microfluidic systems

Mohd Anuar Md Ali, Kostya (Ken) Ostrikov, Fararishah Abdul Khalid, Burhanuddin Y. Majlis, Aminuddin A. Kayani

Research output: Contribution to journalReview ArticleResearchpeer-review

14 Citations (Scopus)

Abstract

The motion of bioparticles in a microfluidic environment can be actively controlled using several tuneable mechanisms, including hydrodynamic, electrophoresis, dielectrophoresis, magnetophoresis, acoustophoresis, thermophoresis and optical forces. These mechanisms are applied to obtain desired bioparticle motions which are important in facilitating different biological processes. In this work, we review the fundamentals, features and applications of these tuneable mechanisms for the manipulation of bioparticles such as proteins, nucleic acids, viruses, bacteria, stem cells, cancer and tumor cells, blood cells and multicellular organisms in microfluidic systems. We focus on applications that can realize biomedical devices potentially suitable in diagnostic, therapeutic or analytical applications. Future perspectives of microfluidic systems incorporating active bioparticle manipulation mechanisms are included.

Original languageEnglish
Pages (from-to)113066-113094
Number of pages29
JournalRSC Advances
Volume6
Issue number114
DOIs
Publication statusPublished - 2016
Externally publishedYes

Cite this

Md Ali, M. A., Ostrikov, K. K., Khalid, F. A., Majlis, B. Y., & Kayani, A. A. (2016). Active bioparticle manipulation in microfluidic systems. RSC Advances, 6(114), 113066-113094. https://doi.org/10.1039/C6RA20080J
Md Ali, Mohd Anuar ; Ostrikov, Kostya (Ken) ; Khalid, Fararishah Abdul ; Majlis, Burhanuddin Y. ; Kayani, Aminuddin A. / Active bioparticle manipulation in microfluidic systems. In: RSC Advances. 2016 ; Vol. 6, No. 114. pp. 113066-113094.
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Md Ali, MA, Ostrikov, KK, Khalid, FA, Majlis, BY & Kayani, AA 2016, 'Active bioparticle manipulation in microfluidic systems', RSC Advances, vol. 6, no. 114, pp. 113066-113094. https://doi.org/10.1039/C6RA20080J

Active bioparticle manipulation in microfluidic systems. / Md Ali, Mohd Anuar; Ostrikov, Kostya (Ken); Khalid, Fararishah Abdul; Majlis, Burhanuddin Y.; Kayani, Aminuddin A.

In: RSC Advances, Vol. 6, No. 114, 2016, p. 113066-113094.

Research output: Contribution to journalReview ArticleResearchpeer-review

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Md Ali MA, Ostrikov KK, Khalid FA, Majlis BY, Kayani AA. Active bioparticle manipulation in microfluidic systems. RSC Advances. 2016;6(114):113066-113094. https://doi.org/10.1039/C6RA20080J