Abstract
The motion of bioparticles in a microfluidic environment can be actively controlled using several tuneable mechanisms, including hydrodynamic, electrophoresis, dielectrophoresis, magnetophoresis, acoustophoresis, thermophoresis and optical forces. These mechanisms are applied to obtain desired bioparticle motions which are important in facilitating different biological processes. In this work, we review the fundamentals, features and applications of these tuneable mechanisms for the manipulation of bioparticles such as proteins, nucleic acids, viruses, bacteria, stem cells, cancer and tumor cells, blood cells and multicellular organisms in microfluidic systems. We focus on applications that can realize biomedical devices potentially suitable in diagnostic, therapeutic or analytical applications. Future perspectives of microfluidic systems incorporating active bioparticle manipulation mechanisms are included.
| Original language | English |
|---|---|
| Pages (from-to) | 113066-113094 |
| Number of pages | 29 |
| Journal | RSC Advances |
| Volume | 6 |
| Issue number | 114 |
| DOIs | |
| Publication status | Published - 2016 |
| Externally published | Yes |
Cite this
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Active bioparticle manipulation in microfluidic systems. / Md Ali, Mohd Anuar; Ostrikov, Kostya (Ken); Khalid, Fararishah Abdul; Majlis, Burhanuddin Y.; Kayani, Aminuddin A.
In: RSC Advances, Vol. 6, No. 114, 2016, p. 113066-113094.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - Active bioparticle manipulation in microfluidic systems
AU - Md Ali, Mohd Anuar
AU - Ostrikov, Kostya (Ken)
AU - Khalid, Fararishah Abdul
AU - Majlis, Burhanuddin Y.
AU - Kayani, Aminuddin A.
PY - 2016
Y1 - 2016
N2 - The motion of bioparticles in a microfluidic environment can be actively controlled using several tuneable mechanisms, including hydrodynamic, electrophoresis, dielectrophoresis, magnetophoresis, acoustophoresis, thermophoresis and optical forces. These mechanisms are applied to obtain desired bioparticle motions which are important in facilitating different biological processes. In this work, we review the fundamentals, features and applications of these tuneable mechanisms for the manipulation of bioparticles such as proteins, nucleic acids, viruses, bacteria, stem cells, cancer and tumor cells, blood cells and multicellular organisms in microfluidic systems. We focus on applications that can realize biomedical devices potentially suitable in diagnostic, therapeutic or analytical applications. Future perspectives of microfluidic systems incorporating active bioparticle manipulation mechanisms are included.
AB - The motion of bioparticles in a microfluidic environment can be actively controlled using several tuneable mechanisms, including hydrodynamic, electrophoresis, dielectrophoresis, magnetophoresis, acoustophoresis, thermophoresis and optical forces. These mechanisms are applied to obtain desired bioparticle motions which are important in facilitating different biological processes. In this work, we review the fundamentals, features and applications of these tuneable mechanisms for the manipulation of bioparticles such as proteins, nucleic acids, viruses, bacteria, stem cells, cancer and tumor cells, blood cells and multicellular organisms in microfluidic systems. We focus on applications that can realize biomedical devices potentially suitable in diagnostic, therapeutic or analytical applications. Future perspectives of microfluidic systems incorporating active bioparticle manipulation mechanisms are included.
UR - http://www.scopus.com/inward/record.url?scp=85002249057&partnerID=8YFLogxK
U2 - 10.1039/C6RA20080J
DO - 10.1039/C6RA20080J
M3 - Review Article
AN - SCOPUS:85002249057
VL - 6
SP - 113066
EP - 113094
JO - RSC Advances
JF - RSC Advances
SN - 2046-2069
IS - 114
ER -