Activation of the innate immune receptors: Guardians of the micro galaxy: Activation and functions of the innate immune receptors

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

7 Citations (Scopus)

Abstract

The families of innate immune receptors are the frontline responders to danger. These superheroes of the host immune systems populate innate immune cells, surveying the extracellular environment and the intracellular endolysosomal compartments and cytosol for exogenous and endogenous danger signals. As a collective the innate immune receptors recognise a wide array of stimuli, and in response they initiate specific signalling pathways leading to activation of transcriptional or proteolytic pathways and the production of inflammatory molecules to destroy foreign pathogens and/or resolve tissue injury. In this review, I will give an overview of the innate immune system and the activation and effector functions of the families of receptors it comprises. Current key concepts will be described throughout, including innate immune memory, formation of innate immune receptor signalosomes, inflammasome formation and pyroptosis, methods of extrinsic cell communication and examples of receptor cooperation. Finally, several open questions and future directions in the field of innate immunity will be presented and discussed.

Original languageEnglish
Title of host publicationRegulation of Inflammatory Signaling in Health and Disease
EditorsDakang Xu
PublisherSpringer
Chapter1
Pages1-35
Number of pages35
ISBN (Electronic)9789811059872
ISBN (Print)9789811059865
DOIs
Publication statusPublished - 1 Jan 2017
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1024
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • CLRs
  • Inflammasomes
  • Innate immune memory
  • Innate immune receptors
  • Innate immunity
  • Myddosome
  • NLRs
  • PRRs
  • RLRs
  • TLRs

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