In vitro studies suggest that activation of the extracellular signal-regulated kinase (ERK) pathway plays a critical role in the proliferation of tubular epithelial and myofibroblast-like cells. However, little is known of ERK activation in individual cell types in normal or diseased kidney. The aims of this study were to (1) localize ERK activation within the kidney, and (2) examine the relationship between ERK activation and cell proliferation in the injured kidney.
Masaki, T., Foti, R., Hill, P. A., Ikezumi, Y., Atkins, R. C., & Nikolic-Paterson, D. J. (2003). Activation of the ERK pathway precedes tubular proliferation in the obstructed rat kidney. Kidney International, 63(4), 1256 - 1264. https://doi.org/10.1046/j.1523-1755.2003.00874.x