Activation of the ERK pathway precedes tubular proliferation in the obstructed rat kidney

Takao Masaki, Rita Foti, Prudence A Hill, Yohei Ikezumi, Robert Charles Atkins, David J Nikolic-Paterson

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Abstract

In vitro studies suggest that activation of the extracellular signal-regulated kinase (ERK) pathway plays a critical role in the proliferation of tubular epithelial and myofibroblast-like cells. However, little is known of ERK activation in individual cell types in normal or diseased kidney. The aims of this study were to (1) localize ERK activation within the kidney, and (2) examine the relationship between ERK activation and cell proliferation in the injured kidney.
Original languageEnglish
Pages (from-to)1256 - 1264
Number of pages9
JournalKidney International
Volume63
Issue number4
DOIs
Publication statusPublished - 2003

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