Activating group recycling in action: A rhodium-catalyzed carbothiolation route to substituted isoquinolines

Milan Arambasic; Joel F. Hooper; Michael C. Willis

doi:10.1021/ol402650q

Activating group recycling in action: A rhodium-catalyzed carbothiolation route to substituted isoquinolines

Milan Arambasic, Joel F. Hooper, Michael C. Willis

Research output: Contribution to journal › Article › Research › peer-review

53 Citations (Scopus)

Abstract

A new rhodium(I) catalyst allows practical and efficient alkyne carbothiolation reactions to be achieved on synthetically useful ketone-bearing aryl methyl sulfides. The carbothiolation adducts, featuring a 'recycled methyl sulfide' activating group, are convenient precursors to highly substituted isoquinolines.

Original language	English
Pages (from-to)	5162-5165
Number of pages	4
Journal	Organic Letters
Volume	15
Issue number	20
DOIs	https://doi.org/10.1021/ol402650q
Publication status	Published - 18 Oct 2013
Externally published	Yes

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10.1021/ol402650q

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title = "Activating group recycling in action: A rhodium-catalyzed carbothiolation route to substituted isoquinolines",

abstract = "A new rhodium(I) catalyst allows practical and efficient alkyne carbothiolation reactions to be achieved on synthetically useful ketone-bearing aryl methyl sulfides. The carbothiolation adducts, featuring a 'recycled methyl sulfide' activating group, are convenient precursors to highly substituted isoquinolines.",

author = "Milan Arambasic and Hooper, {Joel F.} and Willis, {Michael C.}",

year = "2013",

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AU - Hooper, Joel F.

AU - Willis, Michael C.

PY - 2013/10/18

Y1 - 2013/10/18

N2 - A new rhodium(I) catalyst allows practical and efficient alkyne carbothiolation reactions to be achieved on synthetically useful ketone-bearing aryl methyl sulfides. The carbothiolation adducts, featuring a 'recycled methyl sulfide' activating group, are convenient precursors to highly substituted isoquinolines.

AB - A new rhodium(I) catalyst allows practical and efficient alkyne carbothiolation reactions to be achieved on synthetically useful ketone-bearing aryl methyl sulfides. The carbothiolation adducts, featuring a 'recycled methyl sulfide' activating group, are convenient precursors to highly substituted isoquinolines.

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U2 - 10.1021/ol402650q

DO - 10.1021/ol402650q

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SP - 5162

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JO - Organic Letters

JF - Organic Letters

IS - 20

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Activating group recycling in action: A rhodium-catalyzed carbothiolation route to substituted isoquinolines

Abstract

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