Activating group recycling in action: A rhodium-catalyzed carbothiolation route to substituted isoquinolines

Milan Arambasic, Joel F. Hooper, Michael C. Willis

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Abstract

A new rhodium(I) catalyst allows practical and efficient alkyne carbothiolation reactions to be achieved on synthetically useful ketone-bearing aryl methyl sulfides. The carbothiolation adducts, featuring a 'recycled methyl sulfide' activating group, are convenient precursors to highly substituted isoquinolines.

Original languageEnglish
Pages (from-to)5162-5165
Number of pages4
JournalOrganic Letters
Volume15
Issue number20
DOIs
Publication statusPublished - 18 Oct 2013
Externally publishedYes

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