Activating group recycling in action

A rhodium-catalyzed carbothiolation route to substituted isoquinolines

Milan Arambasic, Joel F. Hooper, Michael C. Willis

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Abstract

A new rhodium(I) catalyst allows practical and efficient alkyne carbothiolation reactions to be achieved on synthetically useful ketone-bearing aryl methyl sulfides. The carbothiolation adducts, featuring a 'recycled methyl sulfide' activating group, are convenient precursors to highly substituted isoquinolines.

Original languageEnglish
Pages (from-to)5162-5165
Number of pages4
JournalOrganic Letters
Volume15
Issue number20
DOIs
Publication statusPublished - 18 Oct 2013
Externally publishedYes

Cite this

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abstract = "A new rhodium(I) catalyst allows practical and efficient alkyne carbothiolation reactions to be achieved on synthetically useful ketone-bearing aryl methyl sulfides. The carbothiolation adducts, featuring a 'recycled methyl sulfide' activating group, are convenient precursors to highly substituted isoquinolines.",
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Activating group recycling in action : A rhodium-catalyzed carbothiolation route to substituted isoquinolines. / Arambasic, Milan; Hooper, Joel F.; Willis, Michael C.

In: Organic Letters, Vol. 15, No. 20, 18.10.2013, p. 5162-5165.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Willis, Michael C.

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