Actions of insulin as a survival and growth factor: Akt, mTOR, and regulation of translation

Luc Furic, Mark Livingstone, Ivan Topisirovic, Nahum Sonenberg

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review


Binding of insulin to the insulin receptor (IR) stimulates the receptora??s tyrosine kinase activity. IR activation leads to the recruitment of key activators of downstream pathways via the insulin receptor substrate (IRS) proteins. In a similar fashion, the insulin growth factor-1 receptor (IGF1R) transduces signals to downstream effectors via the PI3K and MAPK pathways.
Original languageEnglish
Title of host publicationInsulin Resistance and Cancer - Epidemiology, Cellular and Molecular Mechanisms and Clinical Implications
EditorsI G Fantus
Place of PublicationUSA
Pages181 - 192
Number of pages12
ISBN (Print)9781441999108
Publication statusPublished - 2011

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