TY - JOUR
T1 - Actinobacteria—a promising natural source of anti-biofilm agents
AU - Azman, Adzzie Shazleen
AU - Mawang, Christina Injan
AU - Khairat, Jasmine Elanie
AU - AbuBakar, Sazaly
PY - 2019/12
Y1 - 2019/12
N2 - A biofilm is a community of microorganisms attached to a surface and embedded in a matrix of extracellular polymeric substances. Biofilms confer resistance towards conventional antibiotic treatments; thus, there is an urgent need for newer and more effective antimicrobial agents that can act against these biofilms. Due to this situation, various studies have been done to investigate the anti-biofilm effects of natural products including bioactive compounds extracted from microorganisms such as Actinobacteria. This review provides an insight into the anti-biofilm potential of Actinobacteria against various pathogenic bacteria, which hopefully provides useful information, guidance, and improvements for future antimicrobial studies. Nevertheless, further research on the anti-biofilm mechanisms and compound modifications to produce more potent anti-biofilm effects are required.
AB - A biofilm is a community of microorganisms attached to a surface and embedded in a matrix of extracellular polymeric substances. Biofilms confer resistance towards conventional antibiotic treatments; thus, there is an urgent need for newer and more effective antimicrobial agents that can act against these biofilms. Due to this situation, various studies have been done to investigate the anti-biofilm effects of natural products including bioactive compounds extracted from microorganisms such as Actinobacteria. This review provides an insight into the anti-biofilm potential of Actinobacteria against various pathogenic bacteria, which hopefully provides useful information, guidance, and improvements for future antimicrobial studies. Nevertheless, further research on the anti-biofilm mechanisms and compound modifications to produce more potent anti-biofilm effects are required.
KW - Actinobacteria
KW - Anti-biofilm
KW - Biofilms
KW - Non-Streptomyces
KW - Streptomyces
UR - http://www.scopus.com/inward/record.url?scp=85065020320&partnerID=8YFLogxK
U2 - 10.1007/s10123-019-00066-4
DO - 10.1007/s10123-019-00066-4
M3 - Review Article
C2 - 30847714
AN - SCOPUS:85065020320
SN - 1139-6709
VL - 22
SP - 403
EP - 409
JO - International Microbiology
JF - International Microbiology
IS - 4
ER -