Acquisition of virulence-associated factors by the enteric pathogens Escherichia coli and Salmonella enterica

J. Wain, D. House, D. Pickard, G. Dougan, G. Frankel

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Abstract

In this review we summarize recent genomic studies that shed light on the mechanism through which pathogenic Escherichia coli and Salmonella enterica have evolved. We show how acquisition of DNA at specific sites on the chromosome has contributed to increased genetic variation and virulence of these two genera of the Enterobacteriaceae.

Original languageEnglish
Pages (from-to)1027-1034
Number of pages8
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume356
Issue number1411
DOIs
Publication statusPublished - 29 Jul 2001
Externally publishedYes

Keywords

  • Enteropathogenic Escherichia coli
  • Horizontal gene transfer
  • Microbial pathogenesis
  • Pathogenicity islands
  • Salmonella

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