Acquisition of invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein 1 in a transmigrant population requires multiple infections

E Elsa Herdiana Murhandarwati, Casilda Gabrielle Black, Lina Wang, Simon Weisman, Tania F de Koning-Ward, J Kevin Baird, Emiliana Tjitra, Thomas L Richie, Brendan S Crabb, Ross Leon Coppel

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Abstract

Antibodies against the 19 kDa C-terminal fragment of merozoite surface protein 1 (MSP1(19)) are a major component of the invasion-inhibitory response in individuals immune to malaria. We report here the acquisition of MSP1(19)-specific invasion-inhibitory antibodies in a group of transmigrants who experienced their sequential malaria infections during settlement in an area of Indonesia where malaria is highly endemic. We used 2 transgenic Plasmodium falciparum parasite lines that expressed either endogenous MSP1(19) or the homologous region from P. chabaudi to measure the MSP1(19)-specific invasion-inhibitory antibodies. The results revealed that the acquisition of MSP1(19)-specific invasion-inhibitory antibodies required 2 or more P. falciparum infections. In contrast, enzyme-linked immunosorbent assays on the same serum samples showed that MSP1(19)-specific antibodies are present after the first malaria infection. This delay in the acquisition of functional antibodies by residents of areas where malaria is endemic is consistent with the observation that multiple malaria infections are required before clinical immunity is acquired.
Original languageEnglish
Pages (from-to)1212 - 1218
Number of pages7
JournalJournal of Infectious Diseases
Volume198
Issue number8
Publication statusPublished - 2008

Cite this

Murhandarwati, E Elsa Herdiana ; Black, Casilda Gabrielle ; Wang, Lina ; Weisman, Simon ; de Koning-Ward, Tania F ; Baird, J Kevin ; Tjitra, Emiliana ; Richie, Thomas L ; Crabb, Brendan S ; Coppel, Ross Leon. / Acquisition of invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein 1 in a transmigrant population requires multiple infections. In: Journal of Infectious Diseases. 2008 ; Vol. 198, No. 8. pp. 1212 - 1218.
@article{a45891d98f4d43779f1ed8dbaee591fd,
title = "Acquisition of invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein 1 in a transmigrant population requires multiple infections",
abstract = "Antibodies against the 19 kDa C-terminal fragment of merozoite surface protein 1 (MSP1(19)) are a major component of the invasion-inhibitory response in individuals immune to malaria. We report here the acquisition of MSP1(19)-specific invasion-inhibitory antibodies in a group of transmigrants who experienced their sequential malaria infections during settlement in an area of Indonesia where malaria is highly endemic. We used 2 transgenic Plasmodium falciparum parasite lines that expressed either endogenous MSP1(19) or the homologous region from P. chabaudi to measure the MSP1(19)-specific invasion-inhibitory antibodies. The results revealed that the acquisition of MSP1(19)-specific invasion-inhibitory antibodies required 2 or more P. falciparum infections. In contrast, enzyme-linked immunosorbent assays on the same serum samples showed that MSP1(19)-specific antibodies are present after the first malaria infection. This delay in the acquisition of functional antibodies by residents of areas where malaria is endemic is consistent with the observation that multiple malaria infections are required before clinical immunity is acquired.",
author = "Murhandarwati, {E Elsa Herdiana} and Black, {Casilda Gabrielle} and Lina Wang and Simon Weisman and {de Koning-Ward}, {Tania F} and Baird, {J Kevin} and Emiliana Tjitra and Richie, {Thomas L} and Crabb, {Brendan S} and Coppel, {Ross Leon}",
year = "2008",
language = "English",
volume = "198",
pages = "1212 -- 1218",
journal = "Journal of Infectious Diseases",
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Murhandarwati, EEH, Black, CG, Wang, L, Weisman, S, de Koning-Ward, TF, Baird, JK, Tjitra, E, Richie, TL, Crabb, BS & Coppel, RL 2008, 'Acquisition of invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein 1 in a transmigrant population requires multiple infections', Journal of Infectious Diseases, vol. 198, no. 8, pp. 1212 - 1218.

Acquisition of invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein 1 in a transmigrant population requires multiple infections. / Murhandarwati, E Elsa Herdiana; Black, Casilda Gabrielle; Wang, Lina; Weisman, Simon; de Koning-Ward, Tania F; Baird, J Kevin; Tjitra, Emiliana; Richie, Thomas L; Crabb, Brendan S; Coppel, Ross Leon.

In: Journal of Infectious Diseases, Vol. 198, No. 8, 2008, p. 1212 - 1218.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Acquisition of invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein 1 in a transmigrant population requires multiple infections

AU - Murhandarwati, E Elsa Herdiana

AU - Black, Casilda Gabrielle

AU - Wang, Lina

AU - Weisman, Simon

AU - de Koning-Ward, Tania F

AU - Baird, J Kevin

AU - Tjitra, Emiliana

AU - Richie, Thomas L

AU - Crabb, Brendan S

AU - Coppel, Ross Leon

PY - 2008

Y1 - 2008

N2 - Antibodies against the 19 kDa C-terminal fragment of merozoite surface protein 1 (MSP1(19)) are a major component of the invasion-inhibitory response in individuals immune to malaria. We report here the acquisition of MSP1(19)-specific invasion-inhibitory antibodies in a group of transmigrants who experienced their sequential malaria infections during settlement in an area of Indonesia where malaria is highly endemic. We used 2 transgenic Plasmodium falciparum parasite lines that expressed either endogenous MSP1(19) or the homologous region from P. chabaudi to measure the MSP1(19)-specific invasion-inhibitory antibodies. The results revealed that the acquisition of MSP1(19)-specific invasion-inhibitory antibodies required 2 or more P. falciparum infections. In contrast, enzyme-linked immunosorbent assays on the same serum samples showed that MSP1(19)-specific antibodies are present after the first malaria infection. This delay in the acquisition of functional antibodies by residents of areas where malaria is endemic is consistent with the observation that multiple malaria infections are required before clinical immunity is acquired.

AB - Antibodies against the 19 kDa C-terminal fragment of merozoite surface protein 1 (MSP1(19)) are a major component of the invasion-inhibitory response in individuals immune to malaria. We report here the acquisition of MSP1(19)-specific invasion-inhibitory antibodies in a group of transmigrants who experienced their sequential malaria infections during settlement in an area of Indonesia where malaria is highly endemic. We used 2 transgenic Plasmodium falciparum parasite lines that expressed either endogenous MSP1(19) or the homologous region from P. chabaudi to measure the MSP1(19)-specific invasion-inhibitory antibodies. The results revealed that the acquisition of MSP1(19)-specific invasion-inhibitory antibodies required 2 or more P. falciparum infections. In contrast, enzyme-linked immunosorbent assays on the same serum samples showed that MSP1(19)-specific antibodies are present after the first malaria infection. This delay in the acquisition of functional antibodies by residents of areas where malaria is endemic is consistent with the observation that multiple malaria infections are required before clinical immunity is acquired.

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M3 - Article

VL - 198

SP - 1212

EP - 1218

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 8

ER -