Acoustically enhanced microfluidic mixer to synthesize highly uniform nanodrugs without the addition of stabilizers

Nguyen Hoai An Le, Hoang Van Phan, Jiaqi Yu, Hak-Kim Chan, Adrian Neild, Tuncay Alan

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: This article presents an acoustically enhanced microfluidic mixer to generate highly uniform and ultra-fine nanoparticles, offering significant advantages over conventional liquid antisolvent techniques. Methods: The method employed a 3D microfluidic geometry whereby two different phases – solvent and antisolvent – were introduced at either side of a 1 μm thick resonating membrane, which contained a through-hole. The vibration of the membrane rapidly and efficiently mixed the two phases, at the location of the hole, leading to the formation of nanoparticles. Results: The versatility of the device was demonstrated by synthesizing budesonide (a common asthma drug) with a mean diameter of 135.7 nm and a polydispersity index of 0.044. Conclusion: The method offers a 40-fold reduction in the size of synthesized particles combined with a substantial improvement in uniformity, achieved without the need of stabilizers.

Original languageEnglish
Pages (from-to)1353-1359
Number of pages7
JournalInternational Journal of Nanomedicine
Volume13
DOIs
Publication statusPublished - 8 Mar 2018

Keywords

  • Budesonide
  • Liquid antisolvent method
  • Microfluidics
  • Nanodrugs

Cite this

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title = "Acoustically enhanced microfluidic mixer to synthesize highly uniform nanodrugs without the addition of stabilizers",
abstract = "Background: This article presents an acoustically enhanced microfluidic mixer to generate highly uniform and ultra-fine nanoparticles, offering significant advantages over conventional liquid antisolvent techniques. Methods: The method employed a 3D microfluidic geometry whereby two different phases – solvent and antisolvent – were introduced at either side of a 1 μm thick resonating membrane, which contained a through-hole. The vibration of the membrane rapidly and efficiently mixed the two phases, at the location of the hole, leading to the formation of nanoparticles. Results: The versatility of the device was demonstrated by synthesizing budesonide (a common asthma drug) with a mean diameter of 135.7 nm and a polydispersity index of 0.044. Conclusion: The method offers a 40-fold reduction in the size of synthesized particles combined with a substantial improvement in uniformity, achieved without the need of stabilizers.",
keywords = "Budesonide, Liquid antisolvent method, Microfluidics, Nanodrugs",
author = "Le, {Nguyen Hoai An} and Phan, {Hoang Van} and Jiaqi Yu and Hak-Kim Chan and Adrian Neild and Tuncay Alan",
year = "2018",
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Acoustically enhanced microfluidic mixer to synthesize highly uniform nanodrugs without the addition of stabilizers. / Le, Nguyen Hoai An; Phan, Hoang Van; Yu, Jiaqi; Chan, Hak-Kim; Neild, Adrian; Alan, Tuncay.

In: International Journal of Nanomedicine, Vol. 13, 08.03.2018, p. 1353-1359.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Acoustically enhanced microfluidic mixer to synthesize highly uniform nanodrugs without the addition of stabilizers

AU - Le, Nguyen Hoai An

AU - Phan, Hoang Van

AU - Yu, Jiaqi

AU - Chan, Hak-Kim

AU - Neild, Adrian

AU - Alan, Tuncay

PY - 2018/3/8

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N2 - Background: This article presents an acoustically enhanced microfluidic mixer to generate highly uniform and ultra-fine nanoparticles, offering significant advantages over conventional liquid antisolvent techniques. Methods: The method employed a 3D microfluidic geometry whereby two different phases – solvent and antisolvent – were introduced at either side of a 1 μm thick resonating membrane, which contained a through-hole. The vibration of the membrane rapidly and efficiently mixed the two phases, at the location of the hole, leading to the formation of nanoparticles. Results: The versatility of the device was demonstrated by synthesizing budesonide (a common asthma drug) with a mean diameter of 135.7 nm and a polydispersity index of 0.044. Conclusion: The method offers a 40-fold reduction in the size of synthesized particles combined with a substantial improvement in uniformity, achieved without the need of stabilizers.

AB - Background: This article presents an acoustically enhanced microfluidic mixer to generate highly uniform and ultra-fine nanoparticles, offering significant advantages over conventional liquid antisolvent techniques. Methods: The method employed a 3D microfluidic geometry whereby two different phases – solvent and antisolvent – were introduced at either side of a 1 μm thick resonating membrane, which contained a through-hole. The vibration of the membrane rapidly and efficiently mixed the two phases, at the location of the hole, leading to the formation of nanoparticles. Results: The versatility of the device was demonstrated by synthesizing budesonide (a common asthma drug) with a mean diameter of 135.7 nm and a polydispersity index of 0.044. Conclusion: The method offers a 40-fold reduction in the size of synthesized particles combined with a substantial improvement in uniformity, achieved without the need of stabilizers.

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