Acoustic-enhanced 3D T junction for nanodrug crystallization

N.H.A. Le; J. Yu; H.V. Phan; A. Neild; H.K. Chan; T. Alan

Acoustic-enhanced 3D T junction for nanodrug crystallization

N.H.A. Le, J. Yu, H.V. Phan, A. Neild, H.K. Chan, T. Alan

Mechanical & Aerospace Engineering

Research output: Contribution to conference › Abstract

Abstract

We present a novel method to generate highly uniform and ultra-fine nanoparticles offering significant improvements to well-established liquid antisolvent techniques. The method relies on a 3D microfluidic geometry, where the solvent and antisolvent phases are separated by a vibrating thin membrane containing a through hole, enhancing the mixing of both phases. The performance of the device was demonstrated through a series of experiments to crystallise 140 nm diameter Budesonide particles, with a polydispersity Index smaller than 0.1. This offers a significant reduction in size compared to earlier well established methods.

Original language	English
Pages	1487-1488
Number of pages	2
Publication status	Published - 2016
Event	International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016) - Convention Center Dublin, Dublin, Ireland Duration: 9 Oct 2016 → 13 Oct 2016 Conference number: 20th

Conference

Conference	International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016)
Abbreviated title	MicroTAS 2016
Country/Territory	Ireland
City	Dublin
Period	9/10/16 → 13/10/16
Other	The Twentieth International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2016) will be held at the Convention Center Dublin in Dublin, IRELAND from 9 - 13 October 2016.

Keywords

Acoustic micromixer
Mechanical resonator
Nanoparticle

Cite this

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title = "Acoustic-enhanced 3D T junction for nanodrug crystallization",

abstract = "We present a novel method to generate highly uniform and ultra-fine nanoparticles offering significant improvements to well-established liquid antisolvent techniques. The method relies on a 3D microfluidic geometry, where the solvent and antisolvent phases are separated by a vibrating thin membrane containing a through hole, enhancing the mixing of both phases. The performance of the device was demonstrated through a series of experiments to crystallise 140 nm diameter Budesonide particles, with a polydispersity Index smaller than 0.1. This offers a significant reduction in size compared to earlier well established methods.",

keywords = "Acoustic micromixer, Mechanical resonator, Nanoparticle",

author = "N.H.A. Le and J. Yu and H.V. Phan and A. Neild and H.K. Chan and T. Alan",

year = "2016",

language = "English",

pages = "1487--1488",

note = "International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), MicroTAS 2016 ; Conference date: 09-10-2016 Through 13-10-2016",

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TY - CONF

T1 - Acoustic-enhanced 3D T junction for nanodrug crystallization

AU - Le, N.H.A.

AU - Yu, J.

AU - Phan, H.V.

AU - Neild, A.

AU - Chan, H.K.

AU - Alan, T.

N1 - Conference code: 20th

PY - 2016

Y1 - 2016

N2 - We present a novel method to generate highly uniform and ultra-fine nanoparticles offering significant improvements to well-established liquid antisolvent techniques. The method relies on a 3D microfluidic geometry, where the solvent and antisolvent phases are separated by a vibrating thin membrane containing a through hole, enhancing the mixing of both phases. The performance of the device was demonstrated through a series of experiments to crystallise 140 nm diameter Budesonide particles, with a polydispersity Index smaller than 0.1. This offers a significant reduction in size compared to earlier well established methods.

AB - We present a novel method to generate highly uniform and ultra-fine nanoparticles offering significant improvements to well-established liquid antisolvent techniques. The method relies on a 3D microfluidic geometry, where the solvent and antisolvent phases are separated by a vibrating thin membrane containing a through hole, enhancing the mixing of both phases. The performance of the device was demonstrated through a series of experiments to crystallise 140 nm diameter Budesonide particles, with a polydispersity Index smaller than 0.1. This offers a significant reduction in size compared to earlier well established methods.

KW - Acoustic micromixer

KW - Mechanical resonator

KW - Nanoparticle

UR - http://www.scopus.com/inward/record.url?scp=85014292694&partnerID=8YFLogxK

M3 - Abstract

AN - SCOPUS:85014292694

SP - 1487

EP - 1488

T2 - International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016)

Y2 - 9 October 2016 through 13 October 2016

ER -

Acoustic-enhanced 3D T junction for nanodrug crystallization

Abstract

Conference

Keywords

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Cite this