Acoustic-enhanced 3D T junction for nanodrug crystallization

N.H.A. Le, J. Yu, H.V. Phan, A. Neild, H.K. Chan, T. Alan

Research output: Contribution to conferenceAbstractOther

Abstract

We present a novel method to generate highly uniform and ultra-fine nanoparticles offering significant improvements to well-established liquid antisolvent techniques. The method relies on a 3D microfluidic geometry, where the solvent and antisolvent phases are separated by a vibrating thin membrane containing a through hole, enhancing the mixing of both phases. The performance of the device was demonstrated through a series of experiments to crystallise 140 nm diameter Budesonide particles, with a polydispersity Index smaller than 0.1. This offers a significant reduction in size compared to earlier well established methods.

Original languageEnglish
Pages1487-1488
Number of pages2
Publication statusPublished - 2016
EventInternational Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016) - Convention Center Dublin, Dublin, Ireland
Duration: 9 Oct 201613 Oct 2016
Conference number: 20th

Conference

ConferenceInternational Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016)
Abbreviated titleMicroTAS 2016
CountryIreland
CityDublin
Period9/10/1613/10/16
OtherThe Twentieth International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2016) will be held at the Convention Center Dublin in Dublin, IRELAND from 9 - 13 October 2016.

Keywords

  • Acoustic micromixer
  • Mechanical resonator
  • Nanoparticle

Cite this

Le, N. H. A., Yu, J., Phan, H. V., Neild, A., Chan, H. K., & Alan, T. (2016). Acoustic-enhanced 3D T junction for nanodrug crystallization. 1487-1488. Abstract from International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), Dublin, Ireland.
Le, N.H.A. ; Yu, J. ; Phan, H.V. ; Neild, A. ; Chan, H.K. ; Alan, T. / Acoustic-enhanced 3D T junction for nanodrug crystallization. Abstract from International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), Dublin, Ireland.2 p.
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Le, NHA, Yu, J, Phan, HV, Neild, A, Chan, HK & Alan, T 2016, 'Acoustic-enhanced 3D T junction for nanodrug crystallization' International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), Dublin, Ireland, 9/10/16 - 13/10/16, pp. 1487-1488.

Acoustic-enhanced 3D T junction for nanodrug crystallization. / Le, N.H.A.; Yu, J.; Phan, H.V.; Neild, A.; Chan, H.K.; Alan, T.

2016. 1487-1488 Abstract from International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), Dublin, Ireland.

Research output: Contribution to conferenceAbstractOther

TY - CONF

T1 - Acoustic-enhanced 3D T junction for nanodrug crystallization

AU - Le, N.H.A.

AU - Yu, J.

AU - Phan, H.V.

AU - Neild, A.

AU - Chan, H.K.

AU - Alan, T.

PY - 2016

Y1 - 2016

N2 - We present a novel method to generate highly uniform and ultra-fine nanoparticles offering significant improvements to well-established liquid antisolvent techniques. The method relies on a 3D microfluidic geometry, where the solvent and antisolvent phases are separated by a vibrating thin membrane containing a through hole, enhancing the mixing of both phases. The performance of the device was demonstrated through a series of experiments to crystallise 140 nm diameter Budesonide particles, with a polydispersity Index smaller than 0.1. This offers a significant reduction in size compared to earlier well established methods.

AB - We present a novel method to generate highly uniform and ultra-fine nanoparticles offering significant improvements to well-established liquid antisolvent techniques. The method relies on a 3D microfluidic geometry, where the solvent and antisolvent phases are separated by a vibrating thin membrane containing a through hole, enhancing the mixing of both phases. The performance of the device was demonstrated through a series of experiments to crystallise 140 nm diameter Budesonide particles, with a polydispersity Index smaller than 0.1. This offers a significant reduction in size compared to earlier well established methods.

KW - Acoustic micromixer

KW - Mechanical resonator

KW - Nanoparticle

UR - http://www.scopus.com/inward/record.url?scp=85014292694&partnerID=8YFLogxK

M3 - Abstract

SP - 1487

EP - 1488

ER -

Le NHA, Yu J, Phan HV, Neild A, Chan HK, Alan T. Acoustic-enhanced 3D T junction for nanodrug crystallization. 2016. Abstract from International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), Dublin, Ireland.