Acoustic-enhanced 3D T junction for nanodrug crystallization

N.H.A. Le, J. Yu, H.V. Phan, A. Neild, H.K. Chan, T. Alan

Research output: Contribution to conferenceAbstract

Abstract

We present a novel method to generate highly uniform and ultra-fine nanoparticles offering significant improvements to well-established liquid antisolvent techniques. The method relies on a 3D microfluidic geometry, where the solvent and antisolvent phases are separated by a vibrating thin membrane containing a through hole, enhancing the mixing of both phases. The performance of the device was demonstrated through a series of experiments to crystallise 140 nm diameter Budesonide particles, with a polydispersity Index smaller than 0.1. This offers a significant reduction in size compared to earlier well established methods.

Original languageEnglish
Pages1487-1488
Number of pages2
Publication statusPublished - 2016
EventInternational Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016) - Convention Center Dublin, Dublin, Ireland
Duration: 9 Oct 201613 Oct 2016
Conference number: 20th

Conference

ConferenceInternational Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016)
Abbreviated titleMicroTAS 2016
CountryIreland
CityDublin
Period9/10/1613/10/16
OtherThe Twentieth International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2016) will be held at the Convention Center Dublin in Dublin, IRELAND from 9 - 13 October 2016.

Keywords

  • Acoustic micromixer
  • Mechanical resonator
  • Nanoparticle

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