Acinetobacter baumannii: emergence of a successful pathogen

Anton Yariv Peleg, Harald Seifert, David L Paterson

Research output: Contribution to journalArticleResearchpeer-review

2603 Citations (Scopus)

Abstract

Acinetobacter baumannii has emerged as a highly troublesome pathogen for many institutions globally. As a consequence of its immense ability to acquire or upregulate antibiotic drug resistance determinants, it has justifiably been propelled to the forefront of scientific attention. Apart from its predilection for the seriously ill within intensive care units, A. baumannii has more recently caused a range of infectious syndromes in military personnel injured in the Iraq and Afghanistan conflicts. This review details the significant advances that have been made in our understanding of this remarkable organism over the last 10 years, including current taxonomy and species identification, issues with susceptibility testing, mechanisms of antibiotic resistance, global epidemiology, clinical impact of infection, host-pathogen interactions, and infection control and therapeutic considerations.
Original languageEnglish
Pages (from-to)538 - 582
Number of pages45
JournalClinical Microbiology Reviews
Volume21
Issue number3
DOIs
Publication statusPublished - 2008
Externally publishedYes

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