Acid/redox dual-activated liposomes for tumor-targeted drug delivery and enhanced therapeutic efficacy

Xuefan Xu; Lei Zhang; Assogba G Assanhou; Lu Wang; Yidi Zhang; Wenyuan Li; Lingjing Xue; Ran Mo; Can Zhang

doi:10.1039/c5ra06445g

Acid/redox dual-activated liposomes for tumor-targeted drug delivery and enhanced therapeutic efficacy

Xuefan Xu
, Lei Zhang
, Assogba G Assanhou
, Lu Wang
, Yidi Zhang
, Wenyuan Li
, Lingjing Xue
, Ran Mo
, Can Zhang

Drug Delivery Disposition & Dynamics

Research output: Contribution to journal › Article › Research › peer-review

20 Citations (Scopus)

Abstract

Acid/redox dual-activated liposomes consisting of a synthetic functional lipid were developed to overcome the multiple barriers to the intravenous delivery of an anticancer drug from the injection site to the target site. The liposome exhibited tumor pH-promoted cellular uptake, endocytic pH-responsive endo-lysosomal escape and redox-triggered intracellular drug release, thereby yielding enhanced antitumor activity.

Original language	English
Pages (from-to)	67803-67808
Number of pages	6
Journal	RSC Advances
Volume	5
Issue number	83
DOIs	https://doi.org/10.1039/c5ra06445g
Publication status	Published - 2015

Access to Document

10.1039/c5ra06445g

Cite this

@article{280bbb1ae4974173a69d51b3a9a8c1ea,

title = "Acid/redox dual-activated liposomes for tumor-targeted drug delivery and enhanced therapeutic efficacy",

abstract = "Acid/redox dual-activated liposomes consisting of a synthetic functional lipid were developed to overcome the multiple barriers to the intravenous delivery of an anticancer drug from the injection site to the target site. The liposome exhibited tumor pH-promoted cellular uptake, endocytic pH-responsive endo-lysosomal escape and redox-triggered intracellular drug release, thereby yielding enhanced antitumor activity.",

author = "Xuefan Xu and Lei Zhang and Assanhou, \{Assogba G\} and Lu Wang and Yidi Zhang and Wenyuan Li and Lingjing Xue and Ran Mo and Can Zhang",

year = "2015",

doi = "10.1039/c5ra06445g",

language = "English",

volume = "5",

pages = "67803--67808",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "The Royal Society of Chemistry",

number = "83",

}

TY - JOUR

T1 - Acid/redox dual-activated liposomes for tumor-targeted drug delivery and enhanced therapeutic efficacy

AU - Xu, Xuefan

AU - Zhang, Lei

AU - Assanhou, Assogba G

AU - Wang, Lu

AU - Zhang, Yidi

AU - Li, Wenyuan

AU - Xue, Lingjing

AU - Mo, Ran

AU - Zhang, Can

PY - 2015

Y1 - 2015

N2 - Acid/redox dual-activated liposomes consisting of a synthetic functional lipid were developed to overcome the multiple barriers to the intravenous delivery of an anticancer drug from the injection site to the target site. The liposome exhibited tumor pH-promoted cellular uptake, endocytic pH-responsive endo-lysosomal escape and redox-triggered intracellular drug release, thereby yielding enhanced antitumor activity.

AB - Acid/redox dual-activated liposomes consisting of a synthetic functional lipid were developed to overcome the multiple barriers to the intravenous delivery of an anticancer drug from the injection site to the target site. The liposome exhibited tumor pH-promoted cellular uptake, endocytic pH-responsive endo-lysosomal escape and redox-triggered intracellular drug release, thereby yielding enhanced antitumor activity.

UR - http://pubs.rsc.org.ezproxy.lib.monash.edu.au/en/content/articlepdf/2015/ra/c5ra06445g

U2 - 10.1039/c5ra06445g

DO - 10.1039/c5ra06445g

M3 - Article

SN - 2046-2069

VL - 5

SP - 67803

EP - 67808

JO - RSC Advances

JF - RSC Advances

IS - 83

ER -

Acid/redox dual-activated liposomes for tumor-targeted drug delivery and enhanced therapeutic efficacy

Abstract

Access to Document

Other files and links

Cite this