Acid/redox dual-activated liposomes consisting of a synthetic functional lipid were developed to overcome the multiple barriers to the intravenous delivery of an anticancer drug from the injection site to the target site. The liposome exhibited tumor pH-promoted cellular uptake, endocytic pH-responsive endo-lysosomal escape and redox-triggered intracellular drug release, thereby yielding enhanced antitumor activity.
Xu, X., Zhang, L., Assanhou, A. G., Wang, L., Zhang, Y., Li, W., Xue, L., Mo, R., & Zhang, C. (2015). Acid/redox dual-activated liposomes for tumor-targeted drug delivery and enhanced therapeutic efficacy. RSC Advances, 5(83), 67803-67808. https://doi.org/10.1039/c5ra06445g