Acid/redox dual-activated liposomes for tumor-targeted drug delivery and enhanced therapeutic efficacy

Xuefan Xu, Lei Zhang, Assogba G Assanhou, Lu Wang, Yidi Zhang, Wenyuan Li, Lingjing Xue, Ran Mo, Can Zhang

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Abstract

Acid/redox dual-activated liposomes consisting of a synthetic functional lipid were developed to overcome the multiple barriers to the intravenous delivery of an anticancer drug from the injection site to the target site. The liposome exhibited tumor pH-promoted cellular uptake, endocytic pH-responsive endo-lysosomal escape and redox-triggered intracellular drug release, thereby yielding enhanced antitumor activity.
Original languageEnglish
Pages (from-to)67803-67808
Number of pages6
JournalRSC Advances
Volume5
Issue number83
DOIs
Publication statusPublished - 2015

Cite this

Xu, X., Zhang, L., Assanhou, A. G., Wang, L., Zhang, Y., Li, W., Xue, L., Mo, R., & Zhang, C. (2015). Acid/redox dual-activated liposomes for tumor-targeted drug delivery and enhanced therapeutic efficacy. RSC Advances, 5(83), 67803-67808. https://doi.org/10.1039/c5ra06445g