Acid-degradable core-crosslinked micelles prepared from thermosensitive glycopolymers synthesized via RAFT polymerization

Ling Zhang, Julien Bernard, Thomas Paul Davis, Christopher Barner-Kowollik, Martina Heide Stenzel

Research output: Contribution to journalArticleResearchpeer-review

129 Citations (Scopus)

Abstract

A thermoresponsive block copolymer, namely poly(acryloyl glucosamine)-block-poly(N-isopropylacryamide) (PAGA180-b-PNIPAAM 350) was simultaneously self-assembled and crosslinked in aqueous medium via RAFT polymerization at 60?C to afford core-crosslinked micelles exhibiting a glycopolymer corona and a PNIPAAM stimuli-responsive core. An acid-labile crosslinking agent, 3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5]- undecane, was employed to generate thermosensitive and acid-degradable core-shell nanoparticles. Stable against degradation at pH = 6 and 8.2, the resulting core crosslinked micelles readily hydrolyzed into well-defined free block copolymers at lower pH (30 min and 12 h respectively at pH = 2 and 4).
Original languageEnglish
Pages (from-to)123 - 129
Number of pages7
JournalMacromolecular Rapid Communications
Volume29
Issue number2
DOIs
Publication statusPublished - 2008
Externally publishedYes

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