TY - JOUR
T1 - Acid-degradable core-crosslinked micelles prepared from thermosensitive glycopolymers synthesized via RAFT polymerization
AU - Zhang, Ling
AU - Bernard, Julien
AU - Davis, Thomas Paul
AU - Barner-Kowollik, Christopher
AU - Stenzel, Martina Heide
PY - 2008
Y1 - 2008
N2 - A thermoresponsive block copolymer, namely poly(acryloyl glucosamine)-block-poly(N-isopropylacryamide) (PAGA180-b-PNIPAAM 350) was simultaneously self-assembled and crosslinked in aqueous medium via RAFT polymerization at 60?C to afford core-crosslinked micelles exhibiting a glycopolymer corona and a PNIPAAM stimuli-responsive core. An acid-labile crosslinking agent, 3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5]- undecane, was employed to generate thermosensitive and acid-degradable core-shell nanoparticles. Stable against degradation at pH = 6 and 8.2, the resulting core crosslinked micelles readily hydrolyzed into well-defined free block copolymers at lower pH (30 min and 12 h respectively at pH = 2 and 4).
AB - A thermoresponsive block copolymer, namely poly(acryloyl glucosamine)-block-poly(N-isopropylacryamide) (PAGA180-b-PNIPAAM 350) was simultaneously self-assembled and crosslinked in aqueous medium via RAFT polymerization at 60?C to afford core-crosslinked micelles exhibiting a glycopolymer corona and a PNIPAAM stimuli-responsive core. An acid-labile crosslinking agent, 3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5]- undecane, was employed to generate thermosensitive and acid-degradable core-shell nanoparticles. Stable against degradation at pH = 6 and 8.2, the resulting core crosslinked micelles readily hydrolyzed into well-defined free block copolymers at lower pH (30 min and 12 h respectively at pH = 2 and 4).
UR - http://onlinelibrary.wiley.com/doi/10.1002/marc.200700663/pdf
U2 - 10.1002/marc.200700663
DO - 10.1002/marc.200700663
M3 - Article
SN - 1022-1336
VL - 29
SP - 123
EP - 129
JO - Macromolecular Rapid Communications
JF - Macromolecular Rapid Communications
IS - 2
ER -