Acetophenone-based linker for solid phase synthesis of secondary amides and sulfonamides on the multipin(TM) support

Chinh T. Bui; Andrew M. Bray; Francesca Ercole; Yen Pham; Firas A. Rasoul; N. Joe Maeji

doi:10.1016/S0040-4039(99)00426-8

Acetophenone-based linker for solid phase synthesis of secondary amides and sulfonamides on the multipin(TM) support

Chinh T. Bui, Andrew M. Bray, Francesca Ercole, Yen Pham, Firas A. Rasoul, N. Joe Maeji

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Abstract

A new and simple linker has been developed for synthesis of secondary amides and sulfonamides. This application is based on the reductive amination reaction between the acetophenone subunit of the linker and a wide range of primary amines including aliphatic and aromatic amines. Cleavage is effected under mild acidic conditions (20% TFA/DCM) to release the products in good yield and purity.

Original language	English
Pages (from-to)	3471-3474
Number of pages	4
Journal	Tetrahedron Letters
Volume	40
Issue number	17
DOIs	https://doi.org/10.1016/S0040-4039(99)00426-8
Publication status	Published - 23 Apr 1999
Externally published	Yes

Access to Document

10.1016/S0040-4039(99)00426-8

Cite this

@article{bd922420c86b490ab1ded8a8e6ba1191,

title = "Acetophenone-based linker for solid phase synthesis of secondary amides and sulfonamides on the multipin(TM) support",

abstract = "A new and simple linker has been developed for synthesis of secondary amides and sulfonamides. This application is based on the reductive amination reaction between the acetophenone subunit of the linker and a wide range of primary amines including aliphatic and aromatic amines. Cleavage is effected under mild acidic conditions (20% TFA/DCM) to release the products in good yield and purity.",

author = "Bui, {Chinh T.} and Bray, {Andrew M.} and Francesca Ercole and Yen Pham and Rasoul, {Firas A.} and Maeji, {N. Joe}",

year = "1999",

month = apr,

day = "23",

doi = "10.1016/S0040-4039(99)00426-8",

language = "English",

volume = "40",

pages = "3471--3474",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier",

number = "17",

}

TY - JOUR

T1 - Acetophenone-based linker for solid phase synthesis of secondary amides and sulfonamides on the multipin(TM) support

AU - Bui, Chinh T.

AU - Bray, Andrew M.

AU - Ercole, Francesca

AU - Pham, Yen

AU - Rasoul, Firas A.

AU - Maeji, N. Joe

PY - 1999/4/23

Y1 - 1999/4/23

N2 - A new and simple linker has been developed for synthesis of secondary amides and sulfonamides. This application is based on the reductive amination reaction between the acetophenone subunit of the linker and a wide range of primary amines including aliphatic and aromatic amines. Cleavage is effected under mild acidic conditions (20% TFA/DCM) to release the products in good yield and purity.

AB - A new and simple linker has been developed for synthesis of secondary amides and sulfonamides. This application is based on the reductive amination reaction between the acetophenone subunit of the linker and a wide range of primary amines including aliphatic and aromatic amines. Cleavage is effected under mild acidic conditions (20% TFA/DCM) to release the products in good yield and purity.

UR - http://www.scopus.com/inward/record.url?scp=0033597354&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(99)00426-8

DO - 10.1016/S0040-4039(99)00426-8

M3 - Article

AN - SCOPUS:0033597354

SN - 0040-4039

VL - 40

SP - 3471

EP - 3474

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 17

ER -

Acetophenone-based linker for solid phase synthesis of secondary amides and sulfonamides on the multipin(TM) support

Abstract

Access to Document

Other files and links

Cite this