Acetophenone-based linker for solid phase synthesis of secondary amides and sulfonamides on the multipin(TM) support

Chinh T. Bui, Andrew M. Bray, Francesca Ercole, Yen Pham, Firas A. Rasoul, N. Joe Maeji

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A new and simple linker has been developed for synthesis of secondary amides and sulfonamides. This application is based on the reductive amination reaction between the acetophenone subunit of the linker and a wide range of primary amines including aliphatic and aromatic amines. Cleavage is effected under mild acidic conditions (20% TFA/DCM) to release the products in good yield and purity.

Original languageEnglish
Pages (from-to)3471-3474
Number of pages4
JournalTetrahedron Letters
Issue number17
Publication statusPublished - 23 Apr 1999
Externally publishedYes

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